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A method for highly selective nucleic acid enrichment for sensitive detection of mutations in cancer and genectic conditions.
Brief Description: This technology increases the fraction of clinically relevant, rare mutant alleles (DNA and/or RNA) to enable high sensitivity detection with common downstream methods such as capped (XNA or PNA) PCR, ddPCR, and sequencing. Motivation:Liquid biopsy is a simple, minimally invasive, rapidly developing diagnostic method to analyz...
Published: 6/24/2019   |   Inventor(s): Jinzhao Song, Haim Bau, Michael Mauk, Jorrit Hegge, John van der Oost
Keywords(s):  
Category(s): Diagnostics, Hardware, Circuits, & Sensors, Medical Devices, Research Tools & Reagents, Veterinary & Animal Health
Method to Determine Risk of Preterm Birth
ProblemPreterm birth accounts for ~12% of all births in the US and costs an estimated $26.2 billion each year. Current methods for identifying patients at risk for preterm birth rely on socioeconomic, behavioral, and clinical factors such as age, tobacco use, or previous preterm birth, respectively. Although there are numerous factors known to be...
Published: 6/13/2019   |   Inventor(s): Michal Elovitz, Jacques Ravel, Pawel Gajer
Keywords(s):  
Category(s): Diagnostics
Portable assay platform for detection of single molecules.
Portable assay platform for detection of single moleculesBrief Description: A simple, inexpensive, and portable lateral flow assay platform that uses platinum nanoparticles to amplify signals and achieve single-molecule sensitivity.Technology:Point-of-care (POC) diagnostics are able to provide rapid on-site results in nonlaboratory settings and pla...
Published: 4/18/2019   |   Inventor(s): Ping Wang
Keywords(s):  
Category(s): Diagnostics
High precision bone metastases and/or fracture identification from dual energy x-ray absorptiometry exams using Artificial Intelligence techniques.
High precision bone metastases and/or fracture identification from dual energy x-ray absorptiometry exams using artificial intelligenceBrief Description Identification of bone metastases and/or fracture with high sensitivity from dual energy x-ray absorptiometry exams using Artificial Intelligence techniques.ProblemOsteoporosis is a disease where b...
Published: 4/5/2019   |   Inventor(s): Ronnie Sebro, Samir Mehta
Keywords(s):  
Category(s): Diagnostics, Software, Data, Algorithms, & Apps
Antibodies for Targeting CAR-T Cells to Neuroendocrine Tumors
Neuroendocrine tumors (NETs) pose serious threats to patients’ well-being as malignant diseases, and most patients with metastatic NETs succumb to the disease. Using Sequential Tumor-related Antibody and antigen Retrieving (STAR) technology Dr. Xianxin Hua, MD, PhD at the University of Pennsylvania Medical School and his team have identified ...
Published: 3/1/2019   |   Inventor(s): Xianxin Hua
Keywords(s):  
Category(s): Diagnostics, Imaging, Therapeutics & Vaccines
Disposable cassette to purify nucleic acids from biological samples for point-of-care diagnostics
Brief Description: Isothermal nucleic acid amplification reactor with integrated solid state membraneTechnology:Researchers in the Bau lab have developed a disposable microfluidic cassette with an integrated porous extraction flow-through membrane for purifying and concentrating nucleic acids from biological samples. The membrane allows decoupling...
Published: 12/4/2018   |   Inventor(s): Haim Bau
Keywords(s):  
Category(s): Diagnostics, Medical Devices, Research Tools & Reagents
Genetically engineered bacteria for oral delivery of bioactive proteins, therapeutics, and vaccines
Lactococcus lactis as vehicle for biotechnological production of proteins and clinical delivery of therapeutics InventorCasim Sarkar, Adjunct Assistant Professor of Bioengineering Technology OverviewThe Sarkar lab has genetically engineered the Gram-positive bacteria Lactococcus lactis to secrete a single-chain insulin analog (SCI-57) that is bioa...
Published: 11/28/2018   |   Inventor(s): Casim Sarkar
Keywords(s): Biomedical Engineering, Biotechnology
Category(s): Diagnostics, Therapeutics & Vaccines
129Xe biosensors for molecular imaging in lungs and brain and potential early detection of breast cancer
Cell-compatible cryptophanes and functionalized 129Xe contrast agents for in vivo highly sensitive NMR and MRI measurements of cancer cellsInventorIvan Dmochowski, Professor of ChemistryProblemCurrent breast cancer screening strategies rely on identifying morphological changes in tissue. There is not a single biomarker to identify early breast can...
Published: 11/27/2018   |   Inventor(s): Ivan Dmochowski
Keywords(s): Biological Sensors , Reagents
Category(s): Diagnostics, Research Tools & Reagents, Imaging
Critical Role of a kinase in breast and colon cancer pathogenesis
The present invention discloses a serine/threonine kinase found to play a critical role in the pathogenesis of breast and colon cancers and is a potential diagnostic, prognostic, and therapeutic target.InventorLewis Chodosh, MD, PhD, Department of Cancer Biology ProblemResults from clinical studies indicate that early full term births result in per...
Published: 11/27/2018   |   Inventor(s): Lewis Chodosh
Keywords(s):  
Category(s): Diagnostics, Therapeutics & Vaccines
Implantable Device to Treat Epilepsy
Diagnostic and preventative implantable device with computer-brain interface for treatment of epilepsy.InventorBrian Litt, MD, Department of Neurology ProblemOne percent of the world’s population suffers from epilepsy. Aside from seizures’ debilitating effects, patients are confined by their unpredictability. Prevention is one way to de...
Published: 11/27/2018   |   Inventor(s): Brian Litt
Keywords(s): Biological Sensors , Biomedical Engineering
Category(s): IT, Communication, & Networking, Diagnostics, Therapeutics & Vaccines, Materials, Medical Devices
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