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Method for Distinguishing “DNA-trapping” and “Non-trapping” PARP Inhibitors
Methodology by which to identify candidate PARP inhibitors with strong anti-cancer properties (i.e. “trapping” compounds), as well as PARP inhibitors with low cellular toxicity for treatment of stroke, diabetes, myocardial infarction, neurodegenerative diseases and other diseases (i.e. a “non-trapping” compounds)Technology I...
Published: 7/29/2019   |   Inventor(s): Ben Black
Keywords(s):  
Category(s): Research Tools & Reagents
Real-Time Angstrom-Resolution Imaging of Proteins Using Light Microscopy
A strategically-designed light microscope setup with data analysis software resolves angstrom-scale protein conformational changes in real time. InventorZhe Lu and John H. LewisProblemProtein conformational changes are intricately involved in their mechanisms of action. This information is key to development of new therapeutic strategies to treat d...
Published: 7/29/2019   |   Inventor(s): Zhe Lu, John Lewis
Keywords(s):  
Category(s): Software, Data, Algorithms, & Apps, Research Tools & Reagents
A method for highly selective nucleic acid enrichment for sensitive detection of mutations in cancer and genectic conditions.
Brief Description: This technology increases the fraction of clinically relevant, rare mutant alleles (DNA and/or RNA) to enable high sensitivity detection with common downstream methods such as capped (XNA or PNA) PCR, ddPCR, and sequencing. Motivation:Liquid biopsy is a simple, minimally invasive, rapidly developing diagnostic method to analyz...
Published: 6/24/2019   |   Inventor(s): Jinzhao Song, Haim Bau, Michael Mauk, Jorrit Hegge, John van der Oost
Keywords(s):  
Category(s): Diagnostics, Hardware, Circuits, & Sensors, Medical Devices, Research Tools & Reagents, Veterinary & Animal Health
Novel “DNA trapping” and “Non-trapping” PARP Inhibitors
Candidate PARPi compounds with strong anti-cancer capabilities (i.e. “DNA trappers”) and PARPi candidates with low cellular toxicity for treatment of stroke, diabetes, myocardial infarction, neurodegenerative diseases and other diseases with PARP overactivation (i.e. “non-trappers”).Technology:Inhibition of Poly(ADP‐ribose) ...
Published: 6/3/2019   |   Inventor(s): Ben Black, Tanaji Talele, John Pascal
Keywords(s):  
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
Application of human 3D brain organoids in regenerative medicine and drug testing.
Human 3D brain organoids for regenerative medicine and drug testingTechnology OverviewCurrent drug discovery strategies often utilize cell lines and animal models forcompound development, drug screening, efficacy testing, and establishing dose-responses. However, such model systems are often limited, particularly for brain disorders and cancers. Tr...
Published: 4/19/2019   |   Inventor(s): Hongjun Song
Keywords(s):  
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
Passive Multidirectional Illumination in Light-Sheet Flourecense Microscopy
Brief Description: Multidirectional Illumination, Light-Sheet Fluorescence Microscopy, Stripe Artifacts Elimination Technology Problem: Light-sheet fluorescence microscopy enables rapid scanning of biological samples to reconstruct a 3-dimensional image of the sample. However, images generally contain artifacts (shadows, stripes, etc.) that are ca...
Published: 3/1/2019   |   Inventor(s): Douglas Durian, Seyyed Muhammad Salili, Matthew Harrington
Keywords(s):  
Category(s): Research Tools & Reagents
Discovery of diazaxanthylidenes for live cell molecular imaging, cell activation, and binding disease-relevant nucleic acids
Brief Description: Synthesis of organelle-specific photoactivatable fluorescent probes for live cell imagingTechnology:The Chenoweth lab has uncovered a synthetic route to generate fluorescent compound libraries from a diazaxanthilidene scaffold of the azaxanthone family that can be used for organelle-specific staining, live cell molecular imaging,...
Published: 3/1/2019   |   Inventor(s): David Chenoweth
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Imaging, Research Tools & Reagents
Antibody Discovery Platform for CAR-T Cell Targeting and Drug Conjugation
Screening platform for identification of potent and specific nanobodies for (i) directing CAR-T cells to cancer cells, (ii) drug conjugation, or (iii) tumor imaging or diagnosis.InventorXianxin Hua, M.D., Ph.D.Identification of antibodies capable of mediating CAR-T killing is challenging due to several reasons. First, the antibody has to have certa...
Published: 3/1/2019   |   Inventor(s): Xianxin Hua
Keywords(s):  
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
Microfabricated device for measuring and manipulating human cardiac tissue
Brief Description: Engineered cardiac microtissues embedded within 3D micropatterned matricesTechnology:Problem: Engineered myocardial tissue is needed to develop organ mimetic models and replace damaged tissue in vivo. Faithfully modeling cardiac tissue biology would enable studies of cardiac physiology and pathophysiology in vitro.Solution: The ...
Published: 3/1/2019   |   Inventor(s): Christopher Chen
Keywords(s):  
Category(s): Medical Devices, Research Tools & Reagents, Therapeutics & Vaccines
Rapid, one-step CRISPR/Cas9-based method for simultaneous bi-allelic editing of a gene
Streamlined CRISPR/Cas9 method allowing for differential modification of two alleles of the same gene and generation of new cell lines in a single reaction. InventorBen E. Black, Ph.D.ProblemGene editing using CRISPR/Cas9 system has led to a recent ‘revolution’ in nearly all eukaryotic systems. Most systems where it could be useful (hum...
Published: 2/26/2019   |   Inventor(s): Ben Black
Keywords(s):  
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
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