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Search Results - Therapeutics & Vaccines

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Gene therapy for achromatopsia
Problem:  There currently is no cure for Achromatopsia which affects up to 1: 50,000 patients in the US. Solution:  Dr. Jean Bennett, MD, PhD, Kirby Professor of Ophthalmology at the University of Pennsylvania’s Perelman School of Medicine, one of the first investigators to develop a gene therapy for a rare inherited form of retinal blindness has...
Published: 4/1/2020   |   Inventor(s): Jean Bennett, Jeannette Bennicelli, Junwei Sun
Keywords(s):  
Category(s): Therapeutics & Vaccines
Gene therapy for optic neuropathy
Problem:  Optic neuritis is a condition commonly observed in MS patients that leads to temporary or permanent visual decline following demyelination of the optic nerve and loss of retinal ganglion cells. Current therapies for MS and ON include immunosuppressive agents that mitigate the inflammatory component of disease. Unfortunately, these treatments...
Published: 4/1/2020   |   Inventor(s): Kenneth Shindler, Devin McDougald, Junwei Sun, Jean Bennett
Keywords(s):  
Category(s): Therapeutics & Vaccines
Implantable biofabricated brain pathways
Tissue engineered nigrostriatal pathway to treat Parkinson's disease Problem:  Parkinson's disease (PD) affects 1-2% of people over 65 with costs estimated at $35 billion a year in the US alone (Global Data). Mitigating PD progression has been estimated to save $450,000 per patient. PD is characterized by uncontrolled tremors and issues with...
Published: 3/20/2020   |   Inventor(s): Daniel Kacy Cullen, Douglas Smith
Keywords(s):  
Category(s): Medical Devices, Therapeutics & Vaccines, Materials
pH Sensitive Nanoparticles for Drug Delivery
Technology Overview:  Many agents used for oncology are either vulnerable to enzymatic attack or are poorly water-soluble, making them difficult to deliver to a tumor site. This invention describes a novel pH-sensitive peptide-based nanoparticle which can provide a precisely targeted method for drug delivery. Rather than relying on uptake of the...
Published: 3/20/2020   |   Inventor(s): I-Wei Chen
Keywords(s):  
Category(s): Therapeutics & Vaccines
Site-specific bioconjugation of native immunoglobulins
Method for covalent cross-linking of antibodies to surfaces for immunoassays and targeted drug delivery   Technology Overview:  The Tsourkas Lab has designed a facile method for the site-specific bioconjugation of native immunoglobulins (IgGs). The researchers have developed novel photoreactive Protein Z variants that allow for the introduction of...
Published: 3/20/2020   |   Inventor(s): Andrew Tsourkas
Keywords(s): Biotechnology, Engineering
Category(s): Chemical Processes and Synthesis, Research Tools & Reagents, Therapeutics & Vaccines, Imaging
Channel modulators as broad-spectrum antivirals
Calcium channel modulating compounds as antivirals for enveloped RNA viruses. Problem:  Hemorrhagic fever viruses such as Ebola, Marburg, and Lassa fever are serious human pathogens for which there are currently no FDA approved therapeutics or vaccines. These viruses are similar to many other enveloped RNA viruses in that therapeutic efforts are...
Published: 3/20/2020   |   Inventor(s): Bruce Freedman
Keywords(s):  
Category(s): Therapeutics & Vaccines
Therapeutic targets for T-cell lymphomas and other types of cancer
Interdependence of oncogenic and epigenetic mechanisms in T-cell lymphoma. Technology Overview: Anaplastic large cell lymphoma (ALCL) is a highly malignant type of Non-Hodgkin’s T cell lymphoma in which chromosomal translocation leads to the expression of a fusion oncoprotein Tyrosine Kinase - Nucleophosmin/Anaplastic Lymphoma Kinase or NPM/ALK. Dr....
Published: 3/20/2020   |   Inventor(s): Mariusz Wasik
Keywords(s): Cancer, DNA, Lymphokines
Category(s): Therapeutics & Vaccines
Enhanced gene transfer for retinal therapies
Technology Overview: While Adeno-Associated Viruses (AAVs) shows great promise in gene therapy applications for the treatment of inherited and acquired retinal diseases, a significant challenge to date has been the limitation of AAV vectors to transduce non-permissive retinal cells and to express in a single cell type.  The inventors have generated...
Published: 3/20/2020   |   Inventor(s): Jean Bennett
Keywords(s):  
Category(s): Therapeutics & Vaccines
New technology for detection of proton therapy beams
Technology Overview: This technology provides a novel proton beam profiling technology with excellent spatial and temporal resolution. Proton radiation therapy is becoming widely adopted for cancer treatment due to its capability of producing maximum dosage within an extremely small area and controlled depth in the tissue. In order to controllably deliver...
Published: 3/20/2020   |   Inventor(s): Robert Hollebeek
Keywords(s):  
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
High potency recombinant IGF-1 biologic
Optimized IGF-1 isoforms have been developed with improved potency in producing muscle hypertrophy. Problem:  Insulin-like growth factor I (IGF-I) is a key regulator of muscle development and growth. However, the complexity of IGF-1 activity is modulated by extensive alternative splicing and glycosylation.  Solution:  A former Penn researcher,...
Published: 3/20/2020   |   Inventor(s): Elisabeth Barton
Keywords(s): Therapeutics
Category(s): Therapeutics & Vaccines
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