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Search Results - Therapeutics & Vaccines

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Targeting the retinoic acid pathway to bolster immunotherapy
A strategy to potentiate immune checkpoint blockade by targeting retinoic acid signaling in immunosuppressive solid tumors.Technology:Sarcomas are solid tumors with more than 70 rare and often fatal subtypes. Typical survival rates are under 15 % over 5 years. Sarcomas can prevent the formation of tumor-killing cells by eluding immune detection, a ...
Published: 6/5/2019   |   Inventor(s): Malay Haldar, Samirkumar Devalaraja
Keywords(s):  
Category(s): Therapeutics & Vaccines
Novel “DNA trapping” and “Non-trapping” PARP Inhibitors
Candidate PARPi compounds with strong anti-cancer capabilities (i.e. “DNA trappers”) and PARPi candidates with low cellular toxicity for treatment of stroke, diabetes, myocardial infarction, neurodegenerative diseases and other diseases with PARP overactivation (i.e. “non-trappers”).Technology:Inhibition of Poly(ADP‐ribose) ...
Published: 6/3/2019   |   Inventor(s): Ben Black, Tanaji Talele, John Pascal
Keywords(s):  
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
Enhancing the Efficacy of Tumor Immunotherapy by Targeting Endothelin Receptor B
Antagonism of Endothelin Receptor B (ETRB) increases intratumoral T cell homing to tumors and enables tumor response to otherwise ineffective immunotherapy TechnologyProblem: In spite of generating a tangible antitumor cellular immune response in peripheral blood, tumor vaccines have proven largely ineffective for treatment of solid tumors. Thesucc...
Published: 5/29/2019   |   Inventor(s): George Coukos
Keywords(s):  
Category(s): Therapeutics & Vaccines
Sweat Your Fat: Topical or Systemic Treatment of Obesity and NASH by Inducing Secretion of Lipids through Skin
Topical treatment leading to upregulation of TSLP, recombinant TSLP, or TSLP expression by viral vectors use for weight loss and weight gain prevention in treatment of obesity, obesity-related disorders, NASH, and Type 2 Diabetes.Technology:Previously Dr. Kambayashi has discovered that topical administration of a vitamin D3 analog MC903 leads to th...
Published: 5/24/2019   |   Inventor(s): Taku Kambayashi
Keywords(s):  
Category(s): Therapeutics & Vaccines
Modified Polymer System for Improved Cartilage Repair
Title: Modified polymer system for improved cartilage repairBrief Description: Improved cartilage repair via injectable modified polymers that target damaged tissues and enhance cellular responseProblem:Cartilage damage is one of the most common ailments in the aging population. Tissue damage, particularly cartilage damage, can occur due to traumat...
Published: 5/22/2019   |   Inventor(s): Jay Patel, Claudia Loebel, Anthony Martin, Robert Mauck, Jason Burdick
Keywords(s):  
Category(s): Therapeutics & Vaccines, Medical Devices
MicroRNA Mimics for the Treatment of Pneumonia
A microRNA mimic accelerates regeneration of lung cells for treatment of bacterial pneumonia and potentially other causes of lung injury. Value PropositionmiR302-mimic is a therapeutic compound that accelerates regeneration of alveolar epithelial cells for treatment of bacterial pneumonia. Unlike standard treatment with antibiotics, which eliminate...
Published: 4/30/2019   |   Inventor(s): Hao Shen
Keywords(s):  
Category(s): Therapeutics & Vaccines
Application of human 3D brain organoids in regenerative medicine and drug testing.
Human 3D brain organoids for regenerative medicine and drug testingTechnology OverviewCurrent drug discovery strategies often utilize cell lines and animal models forcompound development, drug screening, efficacy testing, and establishing dose-responses. However, such model systems are often limited, particularly for brain disorders and cancers. Tr...
Published: 4/19/2019   |   Inventor(s): Hongjun Song
Keywords(s):  
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
Protein Sequences for Therapeutic Applications in Management of Obesity, Cachexia and Nausea
Non-naturally occurring protein sequences that enhance or suppress the activity of hormone associated with obesity and nauseaProblem (or motivation)Growth differentiation factor-15 (GDF15) is a broadly expressed hormone, whose level often correlates with progression of many diseases. It has been shown in multiple species that the elevated level of ...
Published: 3/27/2019   |   Inventor(s): Ian Tinsley, Tito Borner, Robert Doyle, Bart De Jonghe, Matthew Hayes
Keywords(s):  
Category(s): Therapeutics & Vaccines, Veterinary & Animal Health
Method to Treat Heart Failure by Reversing Stiffening of Cardiac Muscle Cells
Brief DescriptionMethods to treat heart failure by interfering and reversing detyrosination of microtubules to restore heart function.ProblemHeart failure (HF) is a chronic condition occurring when the heart muscle doesn't pump blood as well as it should, leading to reduced oxygenation of and blood supply to tissues and organs. Current treatments, ...
Published: 3/15/2019   |   Inventor(s): Benjamin Prosser, Kenneth Margulies
Keywords(s):  
Category(s): Therapeutics & Vaccines
Natural Product Derivatives Kill Dental Cavity Causing Streptococcal Strains
Brief Description: Antibiotics, Dental Cavities, Therapeutics, Oral Bacteria, Honokiol Technology Problem: Early colonizers of dental bacterial infections, such as Streptococcus sanguinis and Streptococcus gordonii, are responsible for early plaque formation by anchoring adhesion proteins to the pellicle of the tooth and producing glucan polymers ...
Published: 3/1/2019   |   Inventor(s): Marisa Kozlowski, William Wuest
Keywords(s):  
Category(s): Therapeutics & Vaccines, Chemical Processes and Synthesis
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