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Stapled peptide therapeutic for the treatment of Herpes Ocular Keratitis
A topically administered stapled peptide prevents Herpes Simplex Virus-1 DNA replication for improved treatment of Herpes Ocular Keratitis.Technology: Nearly two thirds of the world population is infected with Herpes simplex virus-1 (HSV-1). Following initial infection, recurrent activation along the ophthalmic branch of the cranial trigeminal nerv...
Published: 8/22/2019   |   Inventor(s): Robert Ricciardi
Keywords(s):  
Category(s): Therapeutics & Vaccines
Broad non-typeable Haemophilus influenzae vaccine
ProblemHaemophilus influenzae (H. influenzae) colonizes in the upper respiratory tract causing a wide variety of diseases, including otitis media, conjunctivitis, sinusitis, pneumonia, and meningitis. H. influenzae strains are classified into 6 serotypes depending on antibody specificity to the bacterial capsule. There is also a genetically diverse...
Published: 7/30/2019   |   Inventor(s): Hao Shen, Brian Akerley
Keywords(s):  
Category(s): Therapeutics & Vaccines
Therapy Overcoming Resistance of Refractory Prostate Cancer
Inhibition of cyclin-dependent-kinase 7 (CDK7) for treatment of refractory castration-resistant prostate cancer (CRPC) through reduction of androgen receptor transcriptional activity. TechnologyProstate cancer (PCa) is the most common non-cutaneous malignancy and the second leading cause of cancer-related death in men of the western world. While ef...
Published: 7/15/2019   |   Inventor(s): Irfan Asangani
Keywords(s):  
Category(s): Therapeutics & Vaccines
Delayed-Release Hydrogel for the Treatment of Intracranial Glioblastoma
A hydrogel-based implant enables sustained-release delivery of valproic acid for improved treatment of intracranial glioblastoma.ProblemGlioblastoma is the most common primary malignant brain tumor, accounting for 52 percent of all primary brain tumors, and is typically fatal within 15 months after diagnosis. Standard treatment involves tumor resec...
Published: 6/26/2019   |   Inventor(s): Kalil Abdullah, Leo Wang, Jason Burdick
Keywords(s):  
Category(s): Therapeutics & Vaccines
Targeting the retinoic acid pathway to bolster immunotherapy
A strategy to potentiate immune checkpoint blockade by targeting retinoic acid signaling in immunosuppressive solid tumors.Technology:Sarcomas are solid tumors with more than 70 rare and often fatal subtypes. Typical survival rates are under 15 % over 5 years. Sarcomas can prevent the formation of tumor-killing cells by eluding immune detection, a ...
Published: 6/5/2019   |   Inventor(s): Malay Haldar, Samirkumar Devalaraja
Keywords(s):  
Category(s): Therapeutics & Vaccines
Novel “DNA trapping” and “Non-trapping” PARP Inhibitors
Candidate PARPi compounds with strong anti-cancer capabilities (i.e. “DNA trappers”) and PARPi candidates with low cellular toxicity for treatment of stroke, diabetes, myocardial infarction, neurodegenerative diseases and other diseases with PARP overactivation (i.e. “non-trappers”).Technology:Inhibition of Poly(ADP‐ribose) ...
Published: 6/3/2019   |   Inventor(s): Ben Black, Tanaji Talele, John Pascal
Keywords(s):  
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
Enhancing the Efficacy of Tumor Immunotherapy by Targeting Endothelin Receptor B
Antagonism of Endothelin Receptor B (ETRB) increases intratumoral T cell homing to tumors and enables tumor response to otherwise ineffective immunotherapy TechnologyProblem: In spite of generating a tangible antitumor cellular immune response in peripheral blood, tumor vaccines have proven largely ineffective for treatment of solid tumors. Thesucc...
Published: 5/29/2019   |   Inventor(s): George Coukos
Keywords(s):  
Category(s): Therapeutics & Vaccines
Sweat Your Fat: Topical or Systemic Treatment of Obesity and NASH by Inducing Secretion of Lipids through Skin
Topical treatment leading to upregulation of TSLP, recombinant TSLP, or TSLP expression by viral vectors use for weight loss and weight gain prevention in treatment of obesity, obesity-related disorders, NASH, and Type 2 Diabetes.Technology:Previously Dr. Kambayashi has discovered that topical administration of a vitamin D3 analog MC903 leads to th...
Published: 5/24/2019   |   Inventor(s): Taku Kambayashi
Keywords(s):  
Category(s): Therapeutics & Vaccines
Modified Polymer System for Improved Cartilage Repair
Title: Modified polymer system for improved cartilage repairBrief Description: Improved cartilage repair via injectable modified polymers that target damaged tissues and enhance cellular responseProblem:Cartilage damage is one of the most common ailments in the aging population. Tissue damage, particularly cartilage damage, can occur due to traumat...
Published: 5/22/2019   |   Inventor(s): Jay Patel, Claudia Loebel, Anthony Martin, Robert Mauck, Jason Burdick
Keywords(s):  
Category(s): Therapeutics & Vaccines, Medical Devices
MicroRNA Mimics for the Treatment of Pneumonia
A microRNA mimic accelerates regeneration of lung cells for treatment of bacterial pneumonia and potentially other causes of lung injury. Value PropositionmiR302-mimic is a therapeutic compound that accelerates regeneration of alveolar epithelial cells for treatment of bacterial pneumonia. Unlike standard treatment with antibiotics, which eliminate...
Published: 4/30/2019   |   Inventor(s): Hao Shen
Keywords(s):  
Category(s): Therapeutics & Vaccines
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