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Thioamide-modified peptides for stabilized therapeutics and drug development
Natural bioactive peptides and hormones with thioamide substitutions at cleavage sites for improved pharmacokineticsInventorE. James Petersson, Associate Professor of ChemistryProblemNatural bioactive peptides are attractive lead pharmaceutical compounds, but peptides are subjected to rapid proteolysis in vivo. The majority of the time spent in peptide...
Published: 12/4/2019   |   Inventor(s): E. James Petersson
Keywords(s): Biotechnology
Category(s): Chemical Processes and Synthesis, Therapeutics & Vaccines, Materials
Recombinant antibody fragments for targeted treatment of autoimmune skin disease
Brief DescriptionRecombinant antibodies for diagnosis, treatment, and targeted drug delivery in skin disease. TechnologyBullous pemphigoid (BP) is an autoantibody-mediated blistering skin disease in which the epidermal cells lose adhesion to the basement membrane. Patients feature circulating and tissue-bound autoantibodies that target two basement...
Published: 11/15/2019   |   Inventor(s): Matthias Hammers, Donald Siegel, John Stanley
Keywords(s):  
Category(s): Diagnostics, Therapeutics & Vaccines
Stimulator of interferon genes (STING) activation for the treatment of STING-silenced cancer
Brief Description:Expression of mutant STING enables immune activation by DMXAA in STING-silenced cancer cells TechnologyProblem:A promising approach for cancer immunotherapy involves activation of stimulator of interferon genes (STING), a cytosolic sensor that can detect damaged DNA present in cancer cells. STING activation induces cytokine production,...
Published: 11/15/2019   |   Inventor(s): Jianxin You, Wei Liu
Keywords(s):  
Category(s): Therapeutics & Vaccines
Pharmaceutical therapeutic for the treatment of respiratory diseases
Brief Description: Histone deacetylase (HDAC) inhibitors such as Trichostatin A to treat bronchoconstrictive diseases including asthma and chronic obstructive pulmonary disorder (COPD)Technology:Asthma and COPD are diseases of variable airflow obstruction affecting over 40 million Americans. Although some patients respond to conventional therapies,...
Published: 11/14/2019   |   Inventor(s): Jonathan Epstein, Reynold Panettieri
Keywords(s):  
Category(s): Therapeutics & Vaccines
Histone deacetylase (HDAC) and DNA methyltransferase (DNMT) inhibitors for preventative cardiac care and ischemic injury treatment
Brief Description:HDAC and DNMT Inhibitors such as Trichostatin A (TSA) and 5-aza-cytidine are preventative therapies and reduce myocardial infarct volume following cardiac eventsTechnology:Every 40 seconds, someone in the United States has a heart attack. Although several therapeutic options for heart attack recovery exist, ischemic injuries are responsible...
Published: 11/14/2019   |   Inventor(s): Jonathan Epstein, Peter Gruber, Ibrahim Abdullah
Keywords(s):  
Category(s): Therapeutics & Vaccines
CAR-T cell therapy for heart diseases
CAR-T cells targeting cardiac fibroblasts to reduce pathological fibrosis and improve cardiac functionMost forms of heart failure are accompanied by cardiac fibrosis causing a “stiff heart” and contractile dysfunction, which most commonly refers to the excessive deposition of extracellular matrix in the cardiac muscle: fibroblasts become...
Published: 10/23/2019   |   Inventor(s): Haig Aghajanian, Jonathan Epstein
Keywords(s):  
Category(s): Therapeutics & Vaccines
Therapeutic for Type 2 Diabetes and other Obesity-Related Metabolic Disorders
Obesity is associated with buildup of fat within the cells of the liver, heart, and skeletal muscle. Intracellular fat accumulation leads to impairment in the ability of these cells to absorb glucose from the blood in response to insulin- insulin resistance. However, the linkage between intracellular fat accumulation and insulin resistance is poorly...
Published: 9/5/2019   |   Inventor(s): Daniel Kelly, Teresa Leone, Richard Vega, Byungyong Ahn, Satyamaheshwar Peddibhotla, Hampton Sessions
Keywords(s):  
Category(s): Therapeutics & Vaccines
Stapled peptide therapeutic for the treatment of Herpes Ocular Keratitis
A topically administered stapled peptide prevents Herpes Simplex Virus-1 DNA replication for improved treatment of Herpes Ocular Keratitis.Technology: Nearly two thirds of the world population is infected with Herpes simplex virus-1 (HSV-1). Following initial infection, recurrent activation along the ophthalmic branch of the cranial trigeminal nerve...
Published: 8/29/2019   |   Inventor(s): Robert Ricciardi
Keywords(s):  
Category(s): Therapeutics & Vaccines
Chronotherapy Based on Circadian Rhythms
Timed dosing of therapeutic compounds to maximize the efficacy of therapeutics while reducing undesired adverse effects. TechnologyCircadian rhythms are endogenous 24-hour oscillations in behavior and biological processes that respond primarily to light and darkness. The circadian clock drives oscillations in many processes, including sleep, locomotor...
Published: 8/28/2019   |   Inventor(s): John Hogenesch, Garret Fitzgerald
Keywords(s):  
Category(s): Therapeutics & Vaccines
Engineering the Gut Microbiota to Treat Hyperammonemia
Introduction of microbial compositions with minimal activity of ammonia production can alter the microbial community in the gut and reduce overall ammonia production.TechnologyIncreasing evidence indicates (i) that the gut microbiota can be altered to ameliorate or prevent disease states, and (ii) that engineering the gut microbiota to therapeutically...
Published: 8/28/2019   |   Inventor(s): Gary Wu, Frederic Bushman, James Lewis
Keywords(s):  
Category(s): Therapeutics & Vaccines
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