Available Technologies

Browse Penn-owned technologies available for licensing.

HOME SEARCH RSS FEED

Search Results - amos smith

5 Results Sort By:
Reusable silicon-based cross-coupling agents for the production of natural products, pharmaceuticals, and other organic materials
Brief Description: Cross-coupling reactions without the generation of waste productsDocket #: Y6226, 15-7198-----------------------------------------------------------------------------------------------------------------------------------------Technology:Problem: Catalytic carbon-carbon bond formation based on cross-coupling reactions (CCRs) plays...
Published: 12/14/2016   |   Inventor(s): Amos Smith
Keywords(s):  
Category(s): Materials, Research Tools & Reagents, Therapeutics & Vaccines, Chemical Processes and Synthesis
A novel isostere to replace the carboxylic acid functional group in pharmaceuticals and other compounds
Brief Description: Cycloalkyl-dione derivatives with improved pharmacokinetic and toxicological properties for drug designTechnology:Problem: Isosteric replacement of a specific group of atoms with a moiety with similar physicochemical properties is a strategy employed by medicinal chemists to improve the properties of biologically active compounds...
Published: 12/14/2016   |   Inventor(s): Amos Smith, Donna Huryn, Carlo Ballatore, Virginia Lee, John Trojanowski
Keywords(s):  
Category(s): Materials, Therapeutics & Vaccines, Chemical Processes and Synthesis
CD4 mimetic small molecule inhibitors of HIV-1 entry
Brief Description: Therapeutic development for HIV-1 infection and prevention of transmissionTechnology:Problem: A global pandemic of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) persists, with about 34 million people worldwide currently infected and 2.5 million people newly infected with the virus annually. Inh...
Published: 12/14/2016   |   Inventor(s): Amos Smith
Keywords(s):  
Category(s): Therapeutics & Vaccines, Chemical Processes and Synthesis
An efficient method to produce high yield analogs of Hemi-Phorboxazole A with anticancer and antifungal activities
Brief Description: A two-step, high yield, method for synthesizing naturally derived, Hemi-Phorboxazole A analogs Technology:Problem: (+)-Phorboxazole A and B, extracted from the sponge Phorbas sp., display extraordinary anti-proliferative activity against National Cancer Institute’s (NCI) panel of 60 human tumor cell lines. Due to their comp...
Published: 11/30/2016   |   Inventor(s): Amos Smith
Keywords(s):  
Category(s): Therapeutics & Vaccines, Chemical Processes and Synthesis
Phorboxazole compounds as potent anti-tumor agents
Problem: Phorboxazoles are naturally occurring compounds that have been isolated from the marine sponge Phorbas, endemic to the western coast of Australia. Previous screens of phorboxazoles against the National Cancer Institute human cell line panel indicated the most potent cytotoxicity assayed. While the mechanism of action in vivo is unknown, ...
Published: 11/30/2016   |   Inventor(s): Amos Smith
Keywords(s): Cancer
Category(s): Therapeutics & Vaccines, Chemical Processes and Synthesis