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Method for Distinguishing “DNA-trapping” and “Non-trapping” PARP Inhibitors
Methodology by which to identify candidate PARP inhibitors with strong anti-cancer properties (i.e. “trapping” compounds), as well as PARP inhibitors with low cellular toxicity for treatment of stroke, diabetes, myocardial infarction, neurodegenerative diseases and other diseases (i.e. a “non-trapping” compounds)Technology I...
Published: 7/29/2019   |   Inventor(s): Ben Black
Keywords(s):  
Category(s): Research Tools & Reagents
Novel “DNA trapping” and “Non-trapping” PARP Inhibitors
Candidate PARPi compounds with strong anti-cancer capabilities (i.e. “DNA trappers”) and PARPi candidates with low cellular toxicity for treatment of stroke, diabetes, myocardial infarction, neurodegenerative diseases and other diseases with PARP overactivation (i.e. “non-trappers”).Technology:Inhibition of Poly(ADP‐ribose) ...
Published: 6/3/2019   |   Inventor(s): Ben Black, Tanaji Talele, John Pascal
Keywords(s):  
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
Rapid, one-step CRISPR/Cas9-based method for simultaneous bi-allelic editing of a gene
Streamlined CRISPR/Cas9 method allowing for differential modification of two alleles of the same gene and generation of new cell lines in a single reaction. InventorBen E. Black, Ph.D.ProblemGene editing using CRISPR/Cas9 system has led to a recent ‘revolution’ in nearly all eukaryotic systems. Most systems where it could be useful (hum...
Published: 2/26/2019   |   Inventor(s): Ben Black
Keywords(s):  
Category(s): Research Tools & Reagents, Therapeutics & Vaccines