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TIP60 inhibitors – therapy for Irritable Bowel Disease (IBD); ulcerative colitis and Crohn’s diseases
Inhibitors of TIP60, maintaining regulatory T cells (Tregs) and ameliorating autoimmune diseases. ProblemInflammatory bowel disease (IBD) involves chronic inflammation of all or part of digestive tract. IBD includes ulcerative colitis and Crohn’s disease both very prevalent and known to cause severe complications and discomfort. Inhibitors of...
Published: 12/4/2018   |   Inventor(s): Mark Greene
Keywords(s): Biotechnology
Category(s): Therapeutics & Vaccines
Genetically engineered bacteria for oral delivery of bioactive proteins, therapeutics, and vaccines
Lactococcus lactis as vehicle for biotechnological production of proteins and clinical delivery of therapeutics InventorCasim Sarkar, Adjunct Assistant Professor of Bioengineering Technology OverviewThe Sarkar lab has genetically engineered the Gram-positive bacteria Lactococcus lactis to secrete a single-chain insulin analog (SCI-57) that is bioa...
Published: 11/28/2018   |   Inventor(s): Casim Sarkar
Keywords(s): Biomedical Engineering, Biotechnology
Category(s): Diagnostics, Therapeutics & Vaccines
A method to identify modulators for regulatory T cell functions
Docket # T4518 Technology OverviewMaintenance of tolerance to self-antigens is essential for the prevention of autoimmunity. This process is known to involve specific regulatory T cells (Treg) and the expression of the forkhead family transcription factor, FOXP3. FOXP3 is a “sufficient” regulator of the development and function of peri...
Published: 8/10/2017   |   Inventor(s): Mark Greene
Keywords(s): Autoimmune, Biotechnology
Category(s): Research Tools & Reagents
Novel therapeutic use of protein kinase RNA-like endoplasmic reticulum kinase (PERK) inhibitor for acute lung injury treatment
Mitigating lung injury and lung inflammation through PERK pathway inhibitionInventorSusan Margulies, Professor of BioengineeringProblemAcute lung injury, induced by long-term treatment with a mechanical ventilator, and acute respiratory distress syndrome (ARDS) affects 190,000 patients per year in the United States, with associated mortality of 35-...
Published: 5/16/2016   |   Inventor(s): Susan Margulies
Keywords(s): Biotechnology
Category(s): Therapeutics & Vaccines
PET Radiotracers For Quantitative Reporter Gene Imaging
Highly sensitive PET imaging agents for quantitative tracking of gene and cell therapy InventorMark Sellmyer, MD/PhD, Departmentof RadiologyRobert Mach, PhD, Departmentof RadiologyProblemAs gene/cell therapy becomes clinically routine, improved methods to image genetically engineered cells, including immunotherapy, are imperative. Clinicians are i...
Published: 2/11/2016   |   Inventor(s): Mark Sellmyer
Keywords(s): Biological Sensors , Biotechnology
Category(s): Diagnostics, Research Tools & Reagents, Imaging, Chemical Processes and Synthesis
Quantitative, direct imaging of bacterial infection
PET imaging agents for bacterial imaging in people InventorMark Sellmyer, MD/PhD, Departmentof RadiologyRobert Mach, PhD, Departmentof RadiologyProblemThere is an unmet clinical need for improved detection of pathologic bacteria in humans and animals. More specifically, there must be better imaging agents for distinguishing bacterial infection from...
Published: 2/11/2016   |   Inventor(s): Mark Sellmyer
Keywords(s): Biological Sensors , Biotechnology, Dermatology
Category(s): Diagnostics, Research Tools & Reagents, Imaging, Chemical Processes and Synthesis
Repurposing of FDA-approved HER-inhibiting therapies for acute lung injury treatment
Mitigating ventilator-induced lung injury and acute respiratory distress syndrome through HER2/HER3 signaling pathwayInventorSusan Margulies, Professor of BioengineeringProblemAcute lung injury, such as that induced by long-term treatment with a mechanical ventilator, and acute respiratory distress syndrome (ARDS) affects 190,000 patients per year ...
Published: 2/8/2016   |   Inventor(s): Susan Margulies
Keywords(s): Biotechnology
Category(s): Therapeutics & Vaccines
A reverse transcription loop-mediated isothermal amplification method to quantify multiple HIV subtypes
A rapid, quantitative point-of-care diagnostics method for viral load detection of HIV-1 clades A, B, C, D, and GInventorHaim H. Bau, Professor of Mechanical Engineering and Applied MechanicsChangchun Liu, Research Assistant Professor, Mechanical Engineering and Applied MechanicsFrederic D. Bushman, Professor of MicrobiologyProblemHIV infection rem...
Published: 1/20/2016   |   Inventor(s): Haim Bau, Changchun Liu, Frederic Bushman
Keywords(s): Biotechnology, Engineering
Category(s): Diagnostics, Research Tools & Reagents, Medical Devices
Optical probes for real-time nucleic acid detection and gene expression analysis in living cells
Fluorescent ratiometric bimolecular beacons with spatiotemporal resolutionInventorAndrew Tsourkas, Professor of BioengineeringProblemCommon gene expression analysis methods, including polymerase chain reaction, microarrays, and in situ hybridization rely on fixed or lysed cells, hindering their ability to provide spatiotemporal information. This h...
Published: 1/20/2016   |   Inventor(s): Andrew Tsourkas
Keywords(s): Biological Sensors , Biotechnology, Optics & Photonics 
Category(s): Diagnostics, Research Tools & Reagents, Therapeutics & Vaccines, Imaging
Selective phagocytosis of human cancer cells as target for immunotherapy
Cell therapy based methods to reduce tumor growth by disrupting the CD47-SIRPα interaction and targeting cells for phagocytosis with antibodies.InventorDennis Discher, Professor of Chemical and Biomolecular EngineeringProblemCurrent cancer treatments (i.e. radiation, chemotherapy, etc.) result in multiple serious side effects due to lack of t...
Published: 12/23/2015   |   Inventor(s): Dennis Discher
Keywords(s): Biotechnology
Category(s): Therapeutics & Vaccines
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