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Search Results - chemical processes and synthesis

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Antimicrobial polymer layers for medical devices and controlled drug delivery
Stimuli-responsive bilayer coating to prevent bacterial infectionInventorRussell J. Composto, Professor of Materials Science & EngineeringDavid M. Eckmann, Horatio C. Wood Professor of Anesthesiology & Critical CareProblemHospital acquired infections are a leading cause of death in the US, with about 10% of hospitalized patients developing ...
Published: 4/22/2019   |   Inventor(s): Russell Composto, David Eckmann
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Medical Devices
Reconfigurable colloid-crystal materials for fine control over particle motion
Brief Description:A nematic liquid crystal system functionalized with colloidal microbots.Technology:ProblemParticle motion is of great interest for designing materials that depend on the particle behavior to exhibit a specific functionality. Elastic colloids are useful for the development of functional materials for particle manipulation. Nematic ...
Published: 4/16/2019   |   Inventor(s): Kathleen Stebe, Francesca Serra, Yimin Luo
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Materials
Natural Product Derivatives Kill Dental Cavity Causing Streptococcal Strains
Brief Description: Antibiotics, Dental Cavities, Therapeutics, Oral Bacteria, Honokiol Technology Problem: Early colonizers of dental bacterial infections, such as Streptococcus sanguinis and Streptococcus gordonii, are responsible for early plaque formation by anchoring adhesion proteins to the pellicle of the tooth and producing glucan polymers ...
Published: 3/1/2019   |   Inventor(s): Marisa Kozlowski, William Wuest
Keywords(s):  
Category(s): Therapeutics & Vaccines, Chemical Processes and Synthesis
Discovery of diazaxanthylidenes for live cell molecular imaging, cell activation, and binding disease-relevant nucleic acids
Brief Description: Synthesis of organelle-specific photoactivatable fluorescent probes for live cell imagingTechnology:The Chenoweth lab has uncovered a synthetic route to generate fluorescent compound libraries from a diazaxanthilidene scaffold of the azaxanthone family that can be used for organelle-specific staining, live cell molecular imaging,...
Published: 3/1/2019   |   Inventor(s): David Chenoweth
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Imaging, Research Tools & Reagents
Chemical modifications to strengthen and stabilize collagen for biomaterials and biomedicine
Brief Description: Unnatural amino acid substitution for hyperstable collagen-based materialsTechnology: The Chenoweth lab has discovered an unnatural amino acid substitution in collagen to dramatically improve the strength and stability of collagen for a wide range of biomaterial and biomedical applications. More specifically, the researchers have...
Published: 3/1/2019   |   Inventor(s): David Chenoweth
Keywords(s): Bioplastics
Category(s): Chemical Processes and Synthesis, Materials
Synthesis of Arylboronate Esters and Biaryl Compounds
InventorsVirgil PercecBrad RosenChristopher WilsonDaniela WilsonTechnology OverviewIn particular aryl boronate esters and biaryls, are of interest for certain pharmaceutical and electronic material applications. Penn scientists have developed a chemical methodology for the sequential Ni-catalyzed borylation with a novel in-situ prepared reagent an...
Published: 3/1/2019   |   Inventor(s): Virgil Percec, Brad Rosen, Christopher Wilson, Daniela Wilson
Keywords(s):  
Category(s): Chemical Processes and Synthesis
New tandem epoxidation and oxidation reactions for intermediates in asymmetric organic synthesis
Highly enantio- and diastereoselective synthesis of epoxy alcohols from an aldehydeInventorPatrick J. Walsh, Professor of Chemistry and Alan G. MacDiarmid Term ChairProblemAbout half of the top-selling pharmaceuticals are single enantiomers, the precursors of which are chiral substances of high optical purity. Controlling the stereochemistry of th...
Published: 11/27/2018   |   Inventor(s): Patrick Walsh
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Research Tools & Reagents, Materials
One-step synthesis of cationic steroids for gene delivery, anti-inflammatory activity, and antimicrobial activity.
Reagents for improved DNA lipofection, depot anti-inflammation, and/or topical antimicrobial therapyInventorScott L. Diamond, Arthur E. Humphrey Professor of Chemical & Biomolecular EngineeringTechnology OverviewResearchers in the Diamond lab have developed a versatile new class of pharmacologically-active molecules with multiple applications. ...
Published: 11/27/2018   |   Inventor(s): Scott Diamond
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Research Tools & Reagents, Therapeutics & Vaccines
Antimicrobial coating for medical device, biosensor, nanofluidic, and drug delivery applications
Multifunctional, chemically modified chitosan surfaces and charged polymer brushes with protection against microbes and changes in pHInventorsRussell J. Composto, Professor of Materials Science & EngineeringDavid M. Eckmann, Horatio C. Wood Professor of Anesthesiology & Critical CareNoreen J. Hickok, Professor of Biochemistry, Thomas Jeffer...
Published: 1/31/2018   |   Inventor(s): Russell Composto, David Eckmann, Noreen Hickok
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Medical Devices
Adhesive Hydrogels for Wet Applications (Non-Catechol Based)
Brief Description: Biocompatible hydrogels exhibit robust adhesion in wet conditions to substrates with wide range of chemistries and moduli. Technology:Recent interest in developing wet adhesion for biomedical and environmental applications have leveraged catechol-functionalized materials to achieve these results. However, catechol moieties can pr...
Published: 9/15/2017   |   Inventor(s): Laura Bradley, Daeyeon Lee, Kathleen Stebe
Keywords(s):  
Category(s): Materials, Chemical Processes and Synthesis
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