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Adhesive Hydrogels for Wet Applications (Non-Catechol Based)
Brief Description: Biocompatible hydrogels exhibit robust adhesion in wet conditions to substrates with wide range of chemistries and moduli. Technology:Recent interest in developing wet adhesion for biomedical and environmental applications have leveraged catechol-functionalized materials to achieve these results. However, catechol moieties can pr...
Published: 9/15/2017   |   Inventor(s): Laura Bradley, Daeyeon Lee, Kathleen Stebe
Keywords(s):  
Category(s): Materials, Chemical Processes and Synthesis
Scalable, shape-tunable synthesis of non-spherical particles
Brief Description: Non-spherical, highly uniform polystyrene particles as colloidal building blocksTechnology:The Lee lab has expanded on previous research on Janus particles to develop a method for synthesizing non-spherical particles with uniform shape using seeded emulsion polymerization. Linear polystyrene particles are used as a seed for emul...
Published: 2/8/2017   |   Inventor(s): Daeyeon Lee
Keywords(s):  
Category(s): Materials, Research Tools & Reagents, Chemical Processes and Synthesis
One-step generation of stimuli-responsive, multifunctional polyelectrolyte microcapsules
Nanoscale interfacial complexation in emulsions and spontaneous droplet hatching for microcapsulesTechnology:Problem: Polyelectrolyte microcapsules can be prepared by a layer-by-layer assembly method to form nanoengineered shells that are sensitive to external stimuli and enable the encapsulation, protection, and release of active agents. Conventi...
Published: 11/17/2016   |   Inventor(s): Daeyeon Lee
Keywords(s):  
Category(s): Materials, Chemical Processes and Synthesis
High-throughput, highly parallelized, uniform droplet generation
Integrated microfluidic fabrication to expand production to the industrial scaleInventorsDavid Issadore, Assistant Professor of Bioengineering and Electrical & Systems Engineering and Daeyeon Lee, Professor of Chemical & Biomolecular EngineeringProblemDroplet-based microfluidics are being adopted in industry for materials synthesis and poin...
Published: 7/7/2016   |   Inventor(s): David Issadore, Daeyeon Lee
Keywords(s):  
Category(s): Hardware, Circuits, & Sensors, Research Tools & Reagents, Chemical Processes and Synthesis
Click-active Janus particles
Scalable synthesis and functionalization of clickable Janus particles via seeded emulsion polymerizationInventorKathleen Stebe, Deputy Dean for Research & Innovation and Richer & Elizabeth Goodwin Professor of Chemical & Biomolecular Engineering and Daeyeon Lee, Professor of Chemical & Biomolecular EngineeringProblemAmphiphilic Janu...
Published: 6/21/2016   |   Inventor(s): Kathleen Stebe, Daeyeon Lee
Keywords(s):  
Category(s): Materials, Chemical Processes and Synthesis
Novel soft material synthesis with liquid phase architecture and interfacially active particles
Solvent transfer-induced phase separation to tailor bijel fiber propertiesInventors Kathleen Stebe, Deputy Dean for Research & Innovation and Richer & Elizabeth Goodwin Professor of Chemical & Biomolecular Engineering Daeyeon Lee, Professor of Chemical & Biomolecular Engineering ProblemBicontinuous interfacially jammed emulsions (bi...
Published: 6/9/2016   |   Inventor(s): Kathleen Stebe, Daeyeon Lee
Keywords(s):  
Category(s): Materials, Chemical Processes and Synthesis
Polymer nanocomposite films with extremely high nanoparticle loading
Material synthesis through capillary rise infiltrationInventorDaeyeon Lee, Professor of Chemical & Biomolecular EngineeringProblemPolymer nanocomposite films (PNCFs) combine the electronic, mechanical, and optical properties of nanoparticles with the flexibility of polymers to yield nanostructured films. PNCFs with extremely high nanoparticle ...
Published: 3/7/2016   |   Inventor(s): Daeyeon Lee
Keywords(s): Engineering
Category(s): Energy, Infrastructure, & Environment, Materials
pH-responsive, shape changing amphiphilic Janus particles
Stimuli-responsive colloid surfactants for thermodynamically stable emulsions and phase inversion emulsificationInventorDaeyeon Lee, Professor of Chemical & Biomolecular EngineeringProblemJanus particles are biphasic colloids that have distinct chemistries and contrasting properties on each side. Because of their amphiphilicity, Janus particle...
Published: 3/7/2016   |   Inventor(s): Daeyeon Lee
Keywords(s): Engineering
Category(s): Energy, Infrastructure, & Environment, Materials
Fabricating Specialized Oleosins: From Surfactants to Drug Delivery to Imaging
Docket # X5754, 14-7127, 15-7195 ProblemThe fabrication of novel biomaterials can suffer from difficulty of fabrication or lack of control over the end product (e.g. uniformity of size of nanoparticle). Further, modern techniques have been developed to functionalize novel biomaterials, but these methods often require time, cost, and effort in post...
Published: 5/18/2015   |   Inventor(s): Daniel Hammer, Daeyeon Lee
Keywords(s): Biological Materials, Biotechnology, Imaging, MRI, Nanotechnology, Ultrasound
Category(s): Materials
A drug delivery system tuned to the endogenous mechanical environment
Docket # 15-7304Technology OverviewTissues within the body experience mechanical perturbations across multiple force magnitudes and length scales, from mechanotransduction at the cell level to the dynamics of load-bearing joints. These forces not only maintain tissue homeostasis, but can also initiate degenerative processes when applied at supra-p...
Published: 5/6/2015   |   Inventor(s): Robert Mauck, George Dodge, Daeyeon Lee
Keywords(s): Drug Delivery
Category(s): Therapeutics & Vaccines