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Recombinant antibody fragments for targeted treatment of autoimmune skin disease
Brief DescriptionRecombinant antibodies for diagnosis, treatment, and targeted drug delivery in skin disease. TechnologyBullous pemphigoid (BP) is an autoantibody-mediated blistering skin disease in which the epidermal cells lose adhesion to the basement membrane. Patients feature circulating and tissue-bound autoantibodies that target two basement...
Published: 11/15/2019   |   Inventor(s): Matthias Hammers, Donald Siegel, John Stanley
Keywords(s):  
Category(s): Diagnostics, Therapeutics & Vaccines
Method for improved assessment of biomarkers intended for use in healthcare
A probabilistic method to calculate, with improved precision, multiple cutoffs for a continuous biomarker and to classify individual patients into cohorts based on natural variability of a biomarker.TechnologyProblem Biomarkers are a powerful tool for identification of a variety of health conditions and diseases as well as monitoring responses to therapies....
Published: 8/12/2019   |   Inventor(s): Marina Guvakova
Keywords(s):  
Category(s): Diagnostics, Software & Data & Algorithms & Apps
High precision bone metastases and/or fracture identification from dual energy x-ray absorptiometry exams using Artificial Intelligence techniques.
High precision bone metastases and/or fracture identification from dual energy x-ray absorptiometry exams using artificial intelligenceBrief Description Identification of bone metastases and/or fracture with high sensitivity from dual energy x-ray absorptiometry exams using Artificial Intelligence techniques.ProblemOsteoporosis is a disease where bone...
Published: 7/29/2019   |   Inventor(s): Ronnie Sebro, Samir Mehta
Keywords(s):  
Category(s): Diagnostics, Software & Data & Algorithms & Apps
A point-of-care fentanyl test capable of detecting =1 ng/ml fentanyl
Fentanyl is a synthetic opioid agonist that is almost 50-100 times more potent than morphine and illicit fentanyl is the fastest growing overdose substance in the United States. Rapid identification of fentanyl in suspected overdose patients is critical for prompt treatment. This invention describes an easy to use point-of-care test to rapidly identify...
Published: 7/10/2019   |   Inventor(s): Ping Wang, Zhao Li, Hui Chen, Keng-Ku Liu
Keywords(s):  
Category(s): Diagnostics
Early Detection of Pancreatic Cancer
A 2-protein panel blood test for early detection of pancreatic ductal adenocarcinoma.ProblemPancreatic cancer is the third leading cause of cancer related death in the US and is predicted to become the second leading cause of cancer mortality by 2020. Most pancreatic ductal adenocarcinoma (PDAC) patients are diagnosed at an advanced stage of disease,...
Published: 6/26/2019   |   Inventor(s): Kenneth Zaret
Keywords(s):  
Category(s): Diagnostics
A method for highly selective nucleic acid enrichment for sensitive detection of mutations in cancer and genectic conditions.
This technology increases the fraction of clinically relevant, rare mutant alleles (DNA and/or RNA) to enable high sensitivity detection with common downstream methods such as capped (XNA or PNA) PCR, ddPCR, and sequencing. Problem:Liquid biopsy is a simple, minimally invasive, rapidly developing diagnostic method to analyze cell-free nucleic acid fragments...
Published: 6/24/2019   |   Inventor(s): Jinzhao Song, Haim Bau, Michael Mauk, Jorrit Hegge, John van der Oost
Keywords(s):  
Category(s): Diagnostics, Medical Devices, Research Tools & Reagents, Veterinary & Animal Health, Hardware & Circuits & Sensors
Method to Determine Risk of Preterm Birth
ProblemPreterm birth accounts for ~12% of all births in the US and costs an estimated $26.2 billion each year. Current methods for identifying patients at risk for preterm birth rely on socioeconomic, behavioral, and clinical factors such as age, tobacco use, or previous preterm birth, respectively. Although there are numerous factors known to be...
Published: 6/13/2019   |   Inventor(s): Michal Elovitz, Jacques Ravel, Pawel Gajer
Keywords(s):  
Category(s): Diagnostics
Portable assay platform for detection of single molecules.
Portable assay platform for detection of single moleculesBrief Description: A simple, inexpensive, and portable lateral flow assay platform that uses platinum nanoparticles to amplify signals and achieve single-molecule sensitivity.Technology:Point-of-care (POC) diagnostics are able to provide rapid on-site results in non laboratory settings and play...
Published: 4/18/2019   |   Inventor(s): Ping Wang
Keywords(s):  
Category(s): Diagnostics
Disposable cassette to purify nucleic acids from biological samples for point-of-care diagnostics
Brief Description: Isothermal nucleic acid amplification reactor with integrated solid state membraneTechnology:Researchers in the Bau lab have developed a disposable microfluidic cassette with an integrated porous extraction flow-through membrane for purifying and concentrating nucleic acids from biological samples. The membrane allows decoupling...
Published: 12/4/2018   |   Inventor(s): Haim Bau
Keywords(s):  
Category(s): Diagnostics, Medical Devices, Research Tools & Reagents
Genetically engineered bacteria for oral delivery of bioactive proteins, therapeutics, and vaccines
Lactococcus lactis as vehicle for biotechnological production of proteins and clinical delivery of therapeutics InventorCasim Sarkar, Adjunct Assistant Professor of Bioengineering Technology OverviewThe Sarkar lab has genetically engineered the Gram-positive bacteria Lactococcus lactis to secrete a single-chain insulin analog (SCI-57) that is bioactive...
Published: 11/28/2018   |   Inventor(s): Casim Sarkar
Keywords(s): Biomedical Engineering, Biotechnology
Category(s): Diagnostics, Therapeutics & Vaccines
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