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Method for improved assessment of biomarkers intended for use in healthcare
A probabilistic method to calculate, with improved precision, multiple cutoffs for a continuous biomarker and to classify individual patients into cohorts based on natural variability of a biomarker.TechnologyProblem Biomarkers are a powerful tool for identification of a variety of health conditions and diseases as well as monitoring responses to t...
Published: 8/12/2019   |   Inventor(s): Marina Guvakova
Keywords(s):  
Category(s): Diagnostics, Software, Data, Algorithms, & Apps
High precision bone metastases and/or fracture identification from dual energy x-ray absorptiometry exams using Artificial Intelligence techniques.
High precision bone metastases and/or fracture identification from dual energy x-ray absorptiometry exams using artificial intelligenceBrief Description Identification of bone metastases and/or fracture with high sensitivity from dual energy x-ray absorptiometry exams using Artificial Intelligence techniques.ProblemOsteoporosis is a disease where b...
Published: 7/29/2019   |   Inventor(s): Ronnie Sebro, Samir Mehta
Keywords(s):  
Category(s): Diagnostics, Software, Data, Algorithms, & Apps
A point-of-care fentanyl test capable of detecting ‚Č•1 ng/ml fentanyl
Fentanyl is a synthetic opioid agonist that is almost 50-100 times more potent than morphine and illicit fentanyl is the fastest growing overdose substance in the United States. Rapid identification of fentanyl in suspected overdose patients is critical for prompt treatment. This invention describes an easy to use point-of-care test to rapidly iden...
Published: 7/10/2019   |   Inventor(s): Ping Wang, Zhao Li, Hui Chen, Keng-Ku Liu
Keywords(s):  
Category(s): Diagnostics
Early Detection of Pancreatic Cancer
A 2-protein panel blood test for early detection of pancreatic ductal adenocarcinoma.ProblemPancreatic cancer is the third leading cause of cancer related death in the US and is predicted to become the second leading cause of cancer mortality by 2020. Most pancreatic ductal adenocarcinoma (PDAC) patients are diagnosed at an advanced stage of diseas...
Published: 6/26/2019   |   Inventor(s): Kenneth Zaret
Keywords(s):  
Category(s): Diagnostics
A method for highly selective nucleic acid enrichment for sensitive detection of mutations in cancer and genectic conditions.
Brief Description: This technology increases the fraction of clinically relevant, rare mutant alleles (DNA and/or RNA) to enable high sensitivity detection with common downstream methods such as capped (XNA or PNA) PCR, ddPCR, and sequencing. Motivation:Liquid biopsy is a simple, minimally invasive, rapidly developing diagnostic method to analyz...
Published: 6/24/2019   |   Inventor(s): Jinzhao Song, Haim Bau, Michael Mauk, Jorrit Hegge, John van der Oost
Keywords(s):  
Category(s): Diagnostics, Hardware, Circuits, & Sensors, Medical Devices, Research Tools & Reagents, Veterinary & Animal Health
Method to Determine Risk of Preterm Birth
ProblemPreterm birth accounts for ~12% of all births in the US and costs an estimated $26.2 billion each year. Current methods for identifying patients at risk for preterm birth rely on socioeconomic, behavioral, and clinical factors such as age, tobacco use, or previous preterm birth, respectively. Although there are numerous factors known to be...
Published: 6/13/2019   |   Inventor(s): Michal Elovitz, Jacques Ravel, Pawel Gajer
Keywords(s):  
Category(s): Diagnostics
Portable assay platform for detection of single molecules.
Portable assay platform for detection of single moleculesBrief Description: A simple, inexpensive, and portable lateral flow assay platform that uses platinum nanoparticles to amplify signals and achieve single-molecule sensitivity.Technology:Point-of-care (POC) diagnostics are able to provide rapid on-site results in non laboratory settings and pl...
Published: 4/18/2019   |   Inventor(s): Ping Wang
Keywords(s):  
Category(s): Diagnostics
Antibodies for Targeting CAR-T Cells to Neuroendocrine Tumors
Neuroendocrine tumors (NETs) pose serious threats to patients’ well-being as malignant diseases, and most patients with metastatic NETs succumb to the disease. Using Sequential Tumor-related Antibody and antigen Retrieving (STAR) technology Dr. Xianxin Hua, MD, PhD at the University of Pennsylvania Medical School and his team have identified ...
Published: 3/1/2019   |   Inventor(s): Xianxin Hua
Keywords(s):  
Category(s): Diagnostics, Imaging, Therapeutics & Vaccines
Disposable cassette to purify nucleic acids from biological samples for point-of-care diagnostics
Brief Description: Isothermal nucleic acid amplification reactor with integrated solid state membraneTechnology:Researchers in the Bau lab have developed a disposable microfluidic cassette with an integrated porous extraction flow-through membrane for purifying and concentrating nucleic acids from biological samples. The membrane allows decoupling...
Published: 12/4/2018   |   Inventor(s): Haim Bau
Keywords(s):  
Category(s): Diagnostics, Medical Devices, Research Tools & Reagents
Genetically engineered bacteria for oral delivery of bioactive proteins, therapeutics, and vaccines
Lactococcus lactis as vehicle for biotechnological production of proteins and clinical delivery of therapeutics InventorCasim Sarkar, Adjunct Assistant Professor of Bioengineering Technology OverviewThe Sarkar lab has genetically engineered the Gram-positive bacteria Lactococcus lactis to secrete a single-chain insulin analog (SCI-57) that is bioa...
Published: 11/28/2018   |   Inventor(s): Casim Sarkar
Keywords(s): Biomedical Engineering, Biotechnology
Category(s): Diagnostics, Therapeutics & Vaccines
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