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Mutant Cytosine Modifying Enzymes to Enhance Epigenetic or Base-Editing on Genomic DNA

Mutant TET enzymes that stall the oxidation reaction of 5-methylcytosine (5mC) at 5-hydroxymethylcytosine (5hmC), and AID/APOBEC enzymes with hyperactive deamination activity.

Published: 1/12/2024