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Mutant cytosine modifying enzymes to enhance epigenetic or base-editing on genomic DNA
Mutant TET enzymes that stall the oxidation reaction of 5-methylcytosine (5mC) at 5-hydroxymethylcytosine (5hmC), and AID/APOBEC enzymes with hyperactive deamination activity.Inventors Rahul Kohli, M.D., Ph.D., Christopher Nabel, Emily Schitsky, Ph.D, Monica Yun, Ph.DProblemEpigenetic modifications to DNA, such as cytosine methylation, play critica...
Published: 9/7/2018   |   Inventor(s): Rahul Kohli, Christopher Nabel, Emily Schutsky, Monica Yun
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Category(s): Research Tools & Reagents, Therapeutics & Vaccines