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Search Results - haim bau

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A method for highly selective nucleic acid enrichment for sensitive detection of mutations in cancer and genectic conditions.
This technology increases the fraction of clinically relevant, rare mutant alleles (DNA and/or RNA) to enable high sensitivity detection with common downstream methods such as capped (XNA or PNA) PCR, ddPCR, and sequencing. Problem:Liquid biopsy is a simple, minimally invasive, rapidly developing diagnostic method to analyze cell-free nucleic acid ...
Published: 6/24/2019   |   Inventor(s): Jinzhao Song, Haim Bau, Michael Mauk, Jorrit Hegge, John van der Oost
Keywords(s):  
Category(s): Diagnostics, Hardware, Circuits, & Sensors, Medical Devices, Research Tools & Reagents, Veterinary & Animal Health
Disposable cassette to purify nucleic acids from biological samples for point-of-care diagnostics
Brief Description: Isothermal nucleic acid amplification reactor with integrated solid state membraneTechnology:Researchers in the Bau lab have developed a disposable microfluidic cassette with an integrated porous extraction flow-through membrane for purifying and concentrating nucleic acids from biological samples. The membrane allows decoupling...
Published: 12/4/2018   |   Inventor(s): Haim Bau
Keywords(s):  
Category(s): Diagnostics, Medical Devices, Research Tools & Reagents
High efficiency, superhydrophobic clamshell plasma separator for point-of-care diagnostics
Membrane-based, sedimentation-assisted plasma separator InventorHaim H. Bau, Professor of Mechanical Engineering and Applied MechanicsChangchun Liu, Assistant Research ProfessorMichael Mauk, Visiting Assistant Clinical ProfessorProblemHigh sensitivity, point-of-care clinical tests, such as HIV viral load, require large volumes of plasma extracted f...
Published: 1/31/2018   |   Inventor(s): Haim Bau, Changchun Liu, Michael Mauk
Keywords(s): Engineering
Category(s): Diagnostics, Medical Devices
Carbon-based nanopipettes for single cell injection
Multiplexed, nanoscale electrochemical sensor for analyte delivery and detectionInventorHaim H. Bau, Professor of Mechanical Engineering and Applied Mechanics Technology OverviewThe Bau lab has developed carbon-based nanopipettes (CNPs) that allow for reliable single cell injection. These CNPs use an AC electrical impedance measurement to detect c...
Published: 6/1/2017   |   Inventor(s): Haim Bau
Keywords(s): Engineering, Nanotechnology
Category(s): Research Tools & Reagents, Materials
A portable, real-time enzymatic amplification reactor with dry storage of reagents
Brief Description: Point-of-care diagnostic system for nucleic acid-based analysis -----------------------------------------------------------------------------------------------------------------------------------------Technology: The Bau lab has developed a pre-loaded analysis module with reagents stored within a barrier material capab...
Published: 2/8/2017   |   Inventor(s): Haim Bau, Michael Mauk
Keywords(s):  
Category(s): Diagnostics, Medical Devices
A pouch-based cassette for bio-detection with timer-based actuator
Brief Description: Bio-detection cassette with automated actuator for self-contained immunoassay devices and lab-on-a-chip assaysTechnology:The Bau lab has developed a device that sequentially delivers multiple reagents into a microfluidics based lab-on-a-chip system. Protrusions on a rotating wheel sequentially press plastic balls onto flexible d...
Published: 2/8/2017   |   Inventor(s): Haim Bau, Changchun Liu
Keywords(s):  
Category(s): Diagnostics, Medical Devices
A membrane-based, high-efficiency microfluidic debubbler for point-of-care devices
Brief Description: Debubbler for microfluidic systems -----------------------------------------------------------------------------------------------------------------------------------------Technology:Problem: Microfluidic devices often suffer from unwanted bubbles inside a channel, resulting in obstructed fluidic paths, lower reaction efficiency,...
Published: 1/10/2017   |   Inventor(s): Haim Bau, Changchun Liu
Keywords(s):  
Category(s): Diagnostics, Medical Devices, Research Tools & Reagents
A disposable self-heating cartridge for point-of-care molecular diagnostics
Brief Description: A water-activated, self-heating, instrument-free microfluidic diagnostic cartridge-----------------------------------------------------------------------------------------------------------------------------------------Technology:Problem: Many molecular diagnostic devices require elevated temperatures to carry out biochemical rea...
Published: 1/3/2017   |   Inventor(s): Changchun Liu, Haim Bau
Keywords(s):  
Category(s): Diagnostics, Medical Devices, Research Tools & Reagents
A flow cell for electron microscope imaging with multiple flow streams
Brief Description: Nanoaquarium: nanofluidic platform for in situ TEM imaging of fluid-mediated samplesTechnology: Problem: Many nanoscale phenomena occur in liquid media, including nanoparticle and colloidal formation, nanowire liquid phase growth, electrochemical deposition and etching for batteries, and biological interactions. Real-time, in si...
Published: 12/14/2016   |   Inventor(s): Haim Bau
Keywords(s):  
Category(s): Imaging, Research Tools & Reagents
Method and microfluidic chip for two-stage multiplexed isothermal enzymatic amplification
On-chip two-step nucleic acid amplification for point-of-care and clinical molecular detection of multiple diseases and co-infectionsInventorsHaim H. Bau, Professor of Mechanical Engineering & Applied MechanicsChangchun Liu, Assistant Research Professor, Mechanical Engineering & Applied MechanicsProblemPolymerase chain reaction methods (PCR...
Published: 7/8/2016   |   Inventor(s): Haim Bau, Changchun Liu
Keywords(s):  
Category(s): Diagnostics, Medical Devices, Research Tools & Reagents
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