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Search Results - neurodegenerative diseases

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Drug discovery and target identification platform technology using random shRNA-expressing library
shRNA library of 3 million sequences for identification of small-RNA therapeutic candidates, new targets and pathways, as well as conventional chemical-compound drugs in cell-culture disease models. InventorRobert B. Wilson, MD, PhDshRNA Drug DiscoveryProblemRNA interference (RNAi) using short hairpin RNA (shRNA) is commonly used to inhibit gene e...
Published: 1/31/2018   |   Inventor(s): Robert Wilson
Keywords(s): Neurodegenerative Diseases
Category(s): Diagnostics, Therapeutics & Vaccines, Research Tools & Reagents
High spatial and temporal resolution mapping of brain activity using flexible multiplexed electrode arrays with long term stability and safety
Flexible foldable actively multiplexed high density electrode array for mapping brain activity in-vivoInventorBrian Litt, MD, Department of NeurologyProblemElectrode arrays for recording and stimulating the brain are used throughout clinical medicine and basic neuroscience research, but are unable to sample large areas of the brain while maintainin...
Published: 2/4/2016   |   Inventor(s): Brian Litt
Keywords(s): Biological Sensors , Neurodegenerative Diseases
Category(s): Diagnostics, Medical Devices
Measuring and manipulating neuronal signals using implantable electronic microsensor arrays
Self-Adaptive, High Density, Flexible Neuronal Sensor-Effector Microarray for Diagnosis and Treatment of Brain, Spine, Peripheral, and Cardiac NeuropathiesInventorBrian Litt, MD, Department of NeurologyProblemMost current implantable brain devices stimulate large regions of the brain without sensing. These devices are not able to access the fine mu...
Published: 2/3/2016   |   Inventor(s): Brian Litt
Keywords(s): Biological Sensors , Neurodegenerative Diseases
Category(s): Diagnostics, Medical Devices
Classifying high-frequency oscillations in physiological recordings
Method for Automatic and Unsupervised Classification of High-Frequency Oscillations in Physiological Recordings InventorBrian Litt, MD, Department of Neurology ProblemAutomatic detection and classification of high frequency oscillations (HFO) data for use in clinical diagnosis and therapy has been limited. Currently, researchers visually inspect fo...
Published: 2/3/2016   |   Inventor(s): Brian Litt
Keywords(s): Biomedical Engineering, Engineering, Neurodegenerative Diseases
Category(s): Research Tools & Reagents, IT, Communication, & Networking, Imaging, Medical Devices
Novel compounds for treatment for Friedreich Ataxia
Brief DescriptionNew compounds identified through high throughput screening which improve mitochondrial function of Friedreich ataxia cells.Docket # V5006 Technology OverviewBackgroundFriedreich ataxia (FA) is an autosomal recessive, inherited neuro- and cardio-degenerative disorder characterized by progressive ataxia of all four limbs, skeletal d...
Published: 5/12/2015   |   Inventor(s): Robert Wilson
Keywords(s): Neurodegenerative Diseases, Pharmaceuticals, Rare Diseases, Therapeutics
Category(s): Therapeutics & Vaccines
A New Approach to Treat Neurodegenerative Diseases
Technology OverviewAberrant protein folding is severely problematic and manifests in numerous disorders, including amyotrophic lateral sclerosis (ALS), Parkinson disease (PD), Huntington disease (HD), and Alzheimer disease (AD). Patients with each of these disorders are characterized by the accumulation of mislocalized protein deposits. Treatments ...
Published: 5/7/2015   |   Inventor(s): James Shorter, Meredith Jackrel
Keywords(s): Neurodegenerative Diseases, Neurological Disorders
Category(s): Therapeutics & Vaccines