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Search Results - rahul kohli

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Mutant cytosine modifying enzymes to enhance epigenetic or base-editing on genomic DNA
Mutant TET enzymes that stall the oxidation reaction of 5-methylcytosine (5mC) at 5-hydroxymethylcytosine (5hmC), and AID/APOBEC enzymes with hyperactive deamination activity.Inventors Rahul Kohli, M.D., Ph.D., Christopher Nabel, Emily Schitsky, Ph.D, Monica Yun, Ph.DProblemEpigenetic modifications to DNA, such as cytosine methylation, play critical...
Published: 9/7/2018   |   Inventor(s): Rahul Kohli, Christopher Nabel, Emily Schutsky, Monica Yun
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
Novel Activity-Based Probes for TET Enzymatic Activity
Method and probes for detecting and quantifying epigenetic regulator TET enzymatic activity; this method can be used for high throughput screening of TET inhibitors or activators.ProblemTen eleven translocation (TET) enzymes are important epigenetic regulators. TETs catalyze the step-wise oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine...
Published: 6/1/2018   |   Inventor(s): Rahul Kohli
Category(s): Research Tools & Reagents