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An Organometallic Inhibitor for Glycogen Synthase Kinase 3

TechID: Q3604 Since the mid-1990s there has been a near exponential rise in the level of protein kinase and glycogen synthase kinase-3 (GSK-3) directed research. Consequently the therapeutic potential of protein kinase inhibitors in general and GSK-3 inhibitors in particular has become a rapidly growing area of interest to the pharmaceutical in...

Published: Jun 7, 2012 | Inventor(s): Eric Meggers, Howard Bregman, Douglas Williams

Keywords(s): Cancer, Pharmaceuticals

Category(s): Technologies

New Tandem Epoxidation and Oxidation Reactions

TechID: Q3444 Medications sold as single enantiomers comprise 50 of the 100 top selling drugs (e.g. Lipitor, Zyprexa, Nexium, Plavid, Zoloft), and currently represent a $172 billion industry, up from $133 billion in 2000. By 2008, chiral drugs will account for 40% of emerging and updated drug strategies. The precursors of these medications are ...

Published: Jun 7, 2012 | Inventor(s): Patrick Walsh, Alice Lurain, Ann Kelly, Aaron Maestri

Keywords(s): Materials, Pharmaceuticals

Category(s): Technologies

Method for Synthesis of Novel Antibiotics

TechID: O2813 Ramoplanin is among a new class of naturally occurring antibiotics capable of targeting unique enzymatic processes critical for cell wall synthesis in gram-positive bacteria. Ramoplanin is a potent killer of several increasingly prevalent antibiotic resistant species of bacteria including vancomycin-resistant Enterococcus faeci...

Published: Jun 7, 2012 | Inventor(s): Dewey McCafferty, Predrag Cudic

Keywords(s): Antibiotics, Pharmaceuticals

Category(s): Technologies

Catalytic Asymmetric Alkylation of Ketones

TechID: O2788 Medications sold as single enantiomers comprise 50 of the 100 top selling drugs, and currently represent a $133 billion industry, from $90 billion in 1999. The precursors of these medications are chiral substances of high optical purity, which constitute an important class of starting materials for organic and medicinal chemists. Usi...

Published: Jun 7, 2012 | Inventor(s): Patrick Walsh

Keywords(s): Catalyst, Pharmaceuticals

Category(s): Technologies

Synthesis and Use of Reagents for Improved DNA Lipofection and/or Slow Release Prodrug Therapies

TechID: N2612 Researchers at the University of Pennsylvania have developed a versatile new class of pharmacologically-active molecules with multiple applications. In transfection experiments, the molecules deliver genes to cultured cells with considerably more success than commercially available reagents. In addition to their gene delivery c...

Published: Jun 7, 2012 | Inventor(s): Scott Diamond, Jeffrey Gruneich

Keywords(s): Asthma, Chemicals, Gene Delivery, Gene Therapy, Hormone, Pharmaceuticals

Category(s): Technologies

Gene Therapy for Leber's Congenital Amaurosis (LCA) and other early Onset Blinding Diseases

TechID: N2514 A recent study published in the New England Journal of Medicine describe results of a clinical trial performed by researchers from The University of Pennsylvania and the Children’s Hospital of Philadelphia, have used gene therapy to safely restore vision in three young adults with Leber congenital amaurosis (LCA) which is a rare...

Published: Nov 2, 2011 | Inventor(s): Jean Bennett, Albert Maguire, Gregory Acland, Gustavo Aguirre, William Hauswirth, Samuel Jacobson

Keywords(s): Gene Therapy, Ophthalmology

Category(s): Technologies

Novel bisaminoquinoline autophagy inhibitors

NOVEL AUTOPHAGY INHIBITORS Autophagy consists of the sequestration of organelles and proteins in autophagic vesicles (AV), the fusion of AV with lysosomes and the degradation of cargo through the action of acid-dependent lysosomal enzyme. Autophagy allows tumor cells to survive metabolic and therapeutic stresses, and therapy-induced autophagy ...

Published: Jul 18, 2011 | Inventor(s): Ravi Amaravadi, Jeffrey Winkler, Quentin Mcafee, ZhiHui Zhang

Keywords(s):

Category(s): Technologies

Re-engineered stromal cell-derived Factor-1a (SDF) polypertide analog

Synthetic Peptide Improves Cardiac Remodeling Ischemic heart disease affects a large percentage of our population. Therapy includes a complex cocktail of maintenance drugs that seek to improve cardiac function and relieve symptoms. However, the incidence of morbidity is still high due to this disease, and novel therapies are needed. A novel ...

Published: Apr 18, 2011 | Inventor(s): William Hiesinger, Y. Joseph Woo, Jeffery Saven, Jose Mauel Perez-Aguilar

Keywords(s):

Category(s): Technologies

Liquid Injection Closed Circuit Administration of Sevoflurane by Waters' Canister for Cardioversion

TechID: V4965 PORTABLE ECO-FRIENDLY ANESTHESIA SYSTEM Introduction: Brief yet painful medical procedures need patient sedation; however it may be inefficient and difficult to schedule an operating room that has the large anesthesia equipment required for such procedures. In emergency situations large anesthesia equipment may not be availab...

Published: Aug 17, 2010 | Inventor(s): Jeff Mandel, Marcos Amaro

Keywords(s):

Category(s): Technologies

An Oral Appliance for Prevention of Airway Obstruction During Peroral Endoscopy

TechID: T4412 Background: Many patients require sedation when undergoing an endoscopy procedure and, in some cases respiratory obstruction occurs. When inserted in the mouth, this device advances the lower mandible preventing airway collapse. A central lumen allows endoscope insertion and an ancillary lumen are provided for ventilation ...

Published: Jun 15, 2010 | Inventor(s): Jeff Mandel, Marcos Amaro

Keywords(s):

Category(s): Technologies

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