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Search Results - therapeutics & vaccines

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Therapeutic for Type 2 Diabetes and other Obesity-Related Metabolic Disorders
Obesity is associated with buildup of fat within the cells of the liver, heart, and skeletal muscle. Intracellular fat accumulation leads to impairment in the ability of these cells to absorb glucose from the blood in response to insulin- insulin resistance. However, the linkage between intracellular fat accumulation and insulin resistance is poorl...
Published: 9/5/2019   |   Inventor(s): Daniel Kelly, Teresa Leone, Richard Vega, Byungyong Ahn, Satyamaheshwar Peddibhotla, Hampton Sessions
Keywords(s):  
Category(s): Therapeutics & Vaccines
Stapled peptide therapeutic for the treatment of Herpes Ocular Keratitis
A topically administered stapled peptide prevents Herpes Simplex Virus-1 DNA replication for improved treatment of Herpes Ocular Keratitis.Technology: Nearly two thirds of the world population is infected with Herpes simplex virus-1 (HSV-1). Following initial infection, recurrent activation along the ophthalmic branch of the cranial trigeminal nerv...
Published: 8/29/2019   |   Inventor(s): Robert Ricciardi
Keywords(s):  
Category(s): Therapeutics & Vaccines
Chronotherapy Based on Circadian Rhythms
Timed dosing of therapeutic compounds to maximize the efficacy of therapeutics while reducing undesired adverse effects. TechnologyCircadian rhythms are endogenous 24-hour oscillations in behavior and biological processes that respond primarily to light and darkness. The circadian clock drives oscillations in many processes, including sleep, locomo...
Published: 8/28/2019   |   Inventor(s): John Hogenesch, Garret Fitzgerald
Keywords(s):  
Category(s): Therapeutics & Vaccines
Engineering the Gut Microbiota to Treat Hyperammonemia
Introduction of microbial compositions with minimal activity of ammonia production can alter the microbial community in the gut and reduce overall ammonia production.TechnologyIncreasing evidence indicates (i) that the gut microbiota can be altered to ameliorate or prevent disease states, and (ii) that engineering the gut microbiota to therapeutica...
Published: 8/28/2019   |   Inventor(s): Gary Wu, Frederic Bushman, James Lewis
Keywords(s):  
Category(s): Therapeutics & Vaccines
Broad non-typeable Haemophilus influenzae vaccine
ProblemHaemophilus influenzae (H. influenzae) colonizes in the upper respiratory tract causing a wide variety of diseases, including otitis media, conjunctivitis, sinusitis, pneumonia, and meningitis. H. influenzae strains are classified into 6 serotypes depending on antibody specificity to the bacterial capsule. There is also a genetically diverse...
Published: 7/30/2019   |   Inventor(s): Hao Shen, Brian Akerley
Keywords(s):  
Category(s): Therapeutics & Vaccines
Therapy Overcoming Resistance of Refractory Prostate Cancer
Inhibition of cyclin-dependent-kinase 7 (CDK7) for treatment of refractory castration-resistant prostate cancer (CRPC) through reduction of androgen receptor transcriptional activity. TechnologyProstate cancer (PCa) is the most common non-cutaneous malignancy and the second leading cause of cancer-related death in men of the western world. While ef...
Published: 7/15/2019   |   Inventor(s): Irfan Asangani
Keywords(s):  
Category(s): Therapeutics & Vaccines
Delayed-Release Hydrogel for the Treatment of Intracranial Glioblastoma
A hydrogel-based implant enables sustained-release delivery of valproic acid for improved treatment of intracranial glioblastoma.ProblemGlioblastoma is the most common primary malignant brain tumor, accounting for 52 percent of all primary brain tumors, and is typically fatal within 15 months after diagnosis. Standard treatment involves tumor resec...
Published: 6/26/2019   |   Inventor(s): Kalil Abdullah, Leo Wang, Jason Burdick
Keywords(s):  
Category(s): Therapeutics & Vaccines
Targeting the retinoic acid pathway to bolster immunotherapy
A strategy to potentiate immune checkpoint blockade by targeting retinoic acid signaling in immunosuppressive solid tumors.Technology:Sarcomas are solid tumors with more than 70 rare and often fatal subtypes. Typical survival rates are under 15 % over 5 years. Sarcomas can prevent the formation of tumor-killing cells by eluding immune detection, a ...
Published: 6/5/2019   |   Inventor(s): Malay Haldar, Samirkumar Devalaraja
Keywords(s):  
Category(s): Therapeutics & Vaccines
Novel “DNA trapping” and “Non-trapping” PARP Inhibitors
Candidate PARPi compounds with strong anti-cancer capabilities (i.e. “DNA trappers”) and PARPi candidates with low cellular toxicity for treatment of stroke, diabetes, myocardial infarction, neurodegenerative diseases and other diseases with PARP overactivation (i.e. “non-trappers”).Technology:Inhibition of Poly(ADP‐ribose) ...
Published: 6/3/2019   |   Inventor(s): Ben Black, Tanaji Talele, John Pascal
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Category(s): Research Tools & Reagents, Therapeutics & Vaccines
Enhancing the Efficacy of Tumor Immunotherapy by Targeting Endothelin Receptor B
Antagonism of Endothelin Receptor B (ETRB) increases intratumoral T cell homing to tumors and enables tumor response to otherwise ineffective immunotherapy TechnologyProblem: In spite of generating a tangible antitumor cellular immune response in peripheral blood, tumor vaccines have proven largely ineffective for treatment of solid tumors. Thesucc...
Published: 5/29/2019   |   Inventor(s): George Coukos
Keywords(s):  
Category(s): Therapeutics & Vaccines
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