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A drug delivery system tuned to the endogenous mechanical environment

Description:

Docket #  15-7304

 

 

Technology Overview

Tissues within the body experience mechanical perturbations across multiple force magnitudes and length scales, from mechanotransduction at the cell level to the dynamics of load-bearing joints. These forces not only maintain tissue homeostasis, but can also initiate degenerative processes when applied at supra-physiologic levels. Given the centrality of mechanical loading in normal tissue function, Drs. Mauck, Dodge, and Lee at the University of Pennsylvania developed a mechanically activated drug delivery system to stimulate regeneration and repair in mechanically loaded musculoskeletal tissues (e.g. cartilage, muscle, bone).

 

This technology has a wide variety of uses, such as prophylactic treatment of a joint after surgery, prevention of post-traumatic osteoarthritis, and improvement of cartilage regeneration and repair using tissue-engineered cartilage strategies.

 

Advantages

•        Localized delivery

•       Sequential release of therapeutics over a long period of time

•       Ease of maintenance of drug concentration within a therapeutic range

•       Physiologic/self- regulating release

 

 

Inventors

Dr. Robert Mauck:

http://www.med.upenn.edu/apps/faculty/index.php/g20002880/c1924/p5897469

Dr. George Dodge:

http://www.med.upenn.edu/apps/faculty/index.php/g20002880/c1925/p8336972

Dr. Daeyeon Lee:

http://www.seas.upenn.edu/~leegroup/people.html

 

State of Development

•       proof of concept using a model microcapsule system 

 

Intellectual Property

Provisional Patent Filed 

 

 

Reference Media

Tu, Fuquan, and Daeyeon Lee. "Controlling the Stability and Size of Double-Emulsion-Templated Poly(lactic--glycolic) Acid Microcapsules." Langmuir 28.26 (2012): 9944-952.

 

Bhavana Mohanraj et al.  “Mechano-activatable microcapsules for tunable drug delivery” Summer Biomechanics, Bioengineering, and Biotransport Conference, 2015, June 17

 

 

Desired partnerships

Collaboration

 

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Patent Information:
For Information, Contact:
Jeffrey James
TLO
University of Pennsylvania
215-746-7041
jeffja@upenn.edu
Inventors:
Robert Mauck
George Dodge
Daeyeon Lee
Keywords:
Drug Delivery