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Photolinker to Cage Biological Molecules Turn Genes “On” or “Off” with Light

Description:

Docket #  15-7214 

 

Problem

The ability to regulate the structure, function, and/or localization of a biological molecule in an organism could be used to treat many diseases or facilitate basic research. One such example is to turn on or off gene expression in a specific cell or region in an human/organism. Current methods to accomplish this feat are limited and do not allow for specific activation at a given time and locality.

 

Solution

The Dmochowski Lab has developed a new method to “cage” and “uncage” molecules, using a photo-activated linker. This linker is attached to the molecule, such as antisense RNA.

 

The molecule is then caged, silencing it or altering its activity. Exposure to  specific wavelengths of light will activate the photolinker to release the molecule.  

 

Technology Overview

Dmochowski lab has designed a Ruthenium-based  compound, RuBEP, that is  a synthetically versatile photolinker. The photolinker can be tuned to be activated at a large range of visible and near-IR wavelengths, allowing for better tissue penetration and reducing toxicity issues.

 

The photoactivation is incredibly rapid and efficient, occurring on the order of 20 nanoseconds. The photolinker is easily attached using click chemistry and can be used with a variety of biologics, including peptides, oligonucleotides, oligosaccharides, and lipids.

 

Advantages

• Controlled, efficient, and specific activation

• Highly efficient, simple synthesis

• Variable wavelength activation for RuBEP -> Combination of treatments 

 

Applications

• Coatings, Surfactant, Emulsifier

• Vesicle/Nanoparticle

• Microbubble for Ultrasound Usage

• MRI Imaging/Theranostic Agent

 

Inventor

Ivan Dmochowski, PhD

Associate Professor

Department of Chemistry 

 

State of Development

proof of concept,  in vivo data

 

Intellectual Property

Provisional application, file date 8/2014

 

Reference Media

Griepenburg, J.C., et al. Chem. Sci. 2015, 6, 2342-2346 

 

Desired partnerships

• License

• Sponsored research

 

Download PDF

 


Patent Information:
For Information, Contact:
Joshua Jeanson
Associate Director, SEAS/SAS Licensing Group
University of Pennsylvania
jeanson@upenn.edu
Inventors:
Ivan Dmochowski
Keywords:
Biological Materials
Biotechnology
Gene Delivery
RNA