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Fabricating Specialized Oleosins: From Surfactants to Drug Delivery to Imaging

Description:

 

Docket #  X5754, 14-7127, 15-7195 

 

 

Problem

The fabrication of novel biomaterials can suffer from difficulty of fabrication or lack of control over the end product (e.g. uniformity of size of nanoparticle). Further, modern techniques have been developed to functionalize novel biomaterials, but these methods often require time, cost, and effort in post processing.

 

Solution

Taking a page from nature, Drs. Hammer and Lee have leveraged E. Coli to produce a plant protein (oleosin) whose normal biological role is to stabilize plant oil bodies. The result is a collection of nanoparticles of near uniform size. 

 

Technology Overview

The Hammer and Lee labs have developed a method to produce oleosins and functionalized oleosins for a wide variety of applications from surfactants to a drug delivery vehicle to cancer cells. E. Coli can be can be transformed to fabricate oleosin or oleosin with additional molecules, including antibodies and GFP. 

 

Applications

• Coatings, Surfactant, Emulsifier

• Vesicle/Nanoparticle

• Microbubble for Ultrasound Usage

• MRI Imaging/Theranostic Agent

 

Advantages

• Simple method to create functionalized nanoparticles (no post modification step)

• Uniform size of nanoparticle across range of desired sizes

• Nanoparticle size stable over days 

 

Inventor

Daniel  A. Hammer

Alfred G. and Meta A. Ennis Professor Bioengineering and Chemical & Biomolecular Engineering

 

Daeyeon Lee

Professor, Chemical & Biomolecular Engineering

 

State of Development

Proof-of-concept testing

Intellectual Property

USSN 9,238,010

PCT pending (PCT/US2015/036678)

Provisional pending

 

Reference Media

Vargo et al. Small, 2015, 11(12), p. 1409-13.

Vargo et al. Langmuir, 2014, 30(38), p. 11292-300.

Vargo et al. PNAS, 2012, 109(29), p. 11657-62.

 

Desired partnerships

• License

• Sponsored research

 

Download PDF


Patent Information:
Category(s):
Materials
For Information, Contact:
Joshua Jeanson
Associate Director, SEAS/SAS Licensing Group
University of Pennsylvania
jeanson@upenn.edu
Inventors:
Daniel Hammer
Daeyeon Lee
Keywords:
Biological Materials
Biotechnology
Imaging
MRI
Nanotechnology
Ultrasound