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Critical role of a kinase in breast cancer pathogenesis for use in diagnosis, therapy, and prognosis

Description:

SNF1-related serine/threonine kinase was found to play a critical role in the pathogenesis of breast cancers and is a potential diagnostic, prognostic, and therapeutic target.

 

Inventor

Lewis Chodosh, MD, PhD, Department of Cancer Biology

 

Problem

Various studies have shown that estradiol and progesterone play a critical role in the development of breast cancer. Moreover, aberrant expression or mutations of protein kinases have been linked to the pathogenesis of cancer in humans. The identification of a protein or small molecule that provides a molecular target in this pathway would provide significant diagnostic and therapeutic benefit to numerous cancer patients.

 

Solution

This invention relates to the discovery of a SNF1-related serine/threonine kinase and its nucleotide sequence, Hormonally Up-regulated, Neu-Tumor-Associated Kinase (HUNK). HUNK is markedly down regulated in a variety of human breast cancers and provides a useful molecular target for diagnosis, prognosis, and therapy.

  

Advantages

• Use to diagnose ductal and lobular carcinomas of the breast

• Use to screen for a HUNK agonist or antagonist

• Use HUNK or HUNK nucleotide sequence for diagnosis and prognosis of disease

• Use of inverse correlation of HUNK expression and tumor grade for ovarian cancer prognosis  

 

Stage of Development

In-vivo murine data

 

Intellectual Property

• USSN 7,119,185

• USSN 7,368,113

 

Reference Media

Yeh et al. Proc Natl Acad Sci, 2013, 110(15) - 6103-8

Yeh et al. J Clin Invest. 2011, 121(3) - 866-79

Gardner et al. Development. 2000, 127(20) - 4493-509 

 

Desired partnerships

• License

 

 

 

Download PDF

 

Docket # M2335 


Patent Information:
For Information, Contact:
Linara Axanova
Associate Director, PSOM Licensing Group
University of Pennsylvania
axanova@upenn.edu
Inventors:
Lewis Chodosh
Keywords:
Cancer