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Inhibiting immune cell uptake to increase nanoparticle and drug delivery efficiency

Description:

Protection of nanoparticles and viruses from macrophage uptake by conjugation to CD47

 

 

Inventor

Dennis Discher, Professor, Chemical and Biomolecular Engineering 

 

Problem

A major pitfall associated with the use of nanoparticles or viral particles in drug delivery applications is short circulation time, which is partially due to being recognized and taken up by phagocytes or macrophages.  Macrophages engulf molecules coated with IgG antibodies and check for an additional identification via CD47.  Macrophages use the cell surface receptor CD47 to distinguish whether or not a cell or particle should be taken up, with CD47 being the signal to not engulf the foreign body.  CD47 interacts with the immune inhibitory receptor SIRPα found on macrophages.

 

Solution

The Discher lab conjugated human CD47 to nanoparticles or viral particles to allow these particles to be recognized as “self” by the immune system and thereby evade uptake by macrophages. This development increases the delivery efficiency and availability of nanoparticles and viral particles.

 

 

Advantages

•       Increase circulation time of nanoparticle and viral particles

•       Increase delivery efficiency and availability of nanoparticles

•       Low density of conjugated CD47 required for inhibition of macrophage uptake

 

Applications

•       Drug delivery

•       Thwart immune clearance

•       Cancer nanotechnology

 

 

Stage of Development

•       In vitro testing

 

Intellectual Property

USSN 9,050,269

 

Reference Media

NIH Highlight

Penn News highlight 1

Penn News highlight 2

Rodriguez PL, et al.  Science, 2013, 339(6122): 971-975.

Tsai RK, et al.  Journal of Cell Biology, 2008, 180: 989-1003.  Cover Article.

 

 

Desired partnerships

•  License

Co-development

 

 

Download PDF

 

Docket #   V5074 


Patent Information:
For Information, Contact:
Joshua Jeanson
Associate Director, SEAS/SAS Licensing Group
University of Pennsylvania
jeanson@upenn.edu
Inventors:
Dennis Discher
Keywords:
Biotechnology
Nanotechnology