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PET Radiotracers For Quantitative Reporter Gene Imaging

Description:

Nanoparticle based imaging probes have advantages over currently used small molecule agents by carrying a much higher payload of contrast producing material and longer circulation. Bismuth is thought to be the most biocompatible heavy metal, however few syntheses of bismuth nanoparticles for contrast have been achieved. The Cormode lab has successfully formulated a composite bismuth-iron oxide nanoparticle (BION) that is based on clinically approved formulations.

These BION agents work effectively for both CT and MRI purposes. In addition to a prolonged circulation half-life, BION has strong X-ray attenuation and can be used as a T2-weighted MR contrast agent. This bismuth formulation has not shown cytotoxicity and is biodegradable, excreted through urine.

 

Inventor

David Cormode, PhD, Department of Radiology

 

Advantages

• Biocompatible and biodegradable. Easily clears system through urine excretion.

• Much longer circulation half-lives than current contrast agents, allowing for better and extended imaging procedures.

• Inexpensive materials and formulation based on clinically approved formulations.

 

Applications

• Dual imaging probe for both CT and MRI. Similar doses used, allowing for tandem imaging.

 

Stage of Development

Proof of concept

 

Intellectual Property

US application filed

 

Reference Media

Naha et al., 2014; J. Mater. Chem. B, 2014, 2 , 8239.