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Measuring and manipulating neuronal signals using implantable electronic microsensor arrays

Description:

Self-Adaptive, High Density, Flexible Neuronal Sensor-Effector Microarray for Diagnosis and Treatment of Brain, Spine, Peripheral, and Cardiac Neuropathies

 

Inventor

Brian Litt, MD, Department of Neurology

 

Problem

Most current implantable brain devices stimulate large regions of the brain without sensing. These devices are not able to access the fine multiscale architecture comprising brain function and do not interact with the brain’s capacity for self-reorganization and repair.

 

Solution

An implantable electronic micro-sensor array on flexible substrate for the measurement and manipulation of neuronal activity with circuitry to adapt performance based on input patterns. 

  

Advantages

• Very high sensor density (20 nm spacing) improves signal quality and preserves space for effector circuits (electrical stimulators, optical emitters)

• Low temperature fabrication enables use of flexible polymer substrates to better adhere to curved tissue surfaces (brain, spinal cord, heart)

• Self-adaptive circuitry allows optimization of sensor and effector performance post-implantation

 

Applications

• Diagnosis and treatment of Parkinson’s, Alzheimer’s, paralysis, cachexia, and cardiac arrhythmia/ischemia

• Implantable microarrays have been used to facilitate mental control of electronic devices by spinal injury patients

• Implantable cardiac defibrillators  

 

Stage of Development

Prototype arrays have been produced with channel sizes of 60 nm and 20 nm

Prototypes have been used to monitor electrical activity in porcine heart and rat cortex

 

Intellectual Property

U.S. Patent 9,072,887

 

Reference Media

Bink, et al. 2011. Conf Proc IEEE Eng Med Biol Soc, 5400-3. doi: 10.1109/IEMBS.2011.6091335.

 

Desired partnerships

•  License

Collaboration