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Mouse Model of Gastric Cancer

Description:

Rapid, novel mouse model of gastric cancer with metastasis 

 

Inventor

Sandra Ryeom Ph.D., Department of Cancer Biology

  

Technology Overview

UPenn investigators developed a model of mixed type gastric cancer results from combinatorial conditional loss of the Cdh1 (E-cadherin), and p53 genes, and acquisition of expression of oncogenic Kras in gastric parietal cells. Mice exhibit significant disease related morbidity at a median of 77 days of age. Upon gross examination at necropsy 100% of mice present with enlarged, thickened, and whitened stomachs (linea plastic), epigastric lymph node metastases (100%) and mediastinal lymph node metastases (50%). Upon microscopic evaluation the primary tumors were characterized as mixed type gastric cancer containing >25% diffuse type cells. Microscopic observation confirmed the metastatic lesions through the use of the conditional YFP reporter allele (also present in the model) and further identified lung metastases in 100% of mice and liver metastases in 20% of mice.

robust signal to noise and great potential for improving gene/cell immunotherapy.

 

Advantages

• Rapid model of gastric cancer

• 100% penetrance

• Easy to follow disease progression using mouse weight

• Metastasis development that recapitulates progression of human cancer

• Metastasis development in 100% of mice

• Conditional expression of YFP reporter in tumor tissue for tracking of metastatic phenotype

 

Applications

• Drug screening

• Drug validation

• Metastasis Studies

• Microbiome Studies