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Islet ß cells exosome profile as biomarker platform for early diagnosis and monitoring of diabetes

Description:

Quantitative RNA, proteomic, and metabolite profiling of islet β cells-specific exosomes in patient plasma/serum as marker for monitoring metabolic diseases, such as type I or type II diabetes, metabolic syndrome, and obesity.

 

Inventor:

Prashanth Vallabhajosyula, MD

  

Problem:

Metabolic disorders including type I or type II diabetes, morbid obesity, and metabolic syndrome affect over 1/3 of the US population. There is a critical clinical need for biomarker platforms that would allow for early diagnosis, prognosis, and monitoring of these conditions.

 

Solution:

Exosomes are extracellular microvesicles released by many tissue types into bodily fluids. They carry tissue specific RNA and protein cargoes reflecting the conditional status of the originating tissue. Islet β cells are also known to release exosomes that are specific to the tissue. Dr. Vallabhajosyula at Penn discovered that transmembrane protein ion channel regulator FXYD2 is expressed on the surface of the islet β cell exosomes and can be used for isolation and purification of islet β cell-specific exosomes. Islet exosomes demonstrated expression profile differences in type I diabetes patients compared to normal controls, including reduced insulin levels. Inventor currently further analyzes differences in microRNA, long RNA, as well as proteomic and metabolite profiles. Together, ability to isolate islet β cell specific exosomes from patients’ blood can potentially be used as a novel biomarker platform to monitor patients with type I and type II diabetes and other metabolic diseases.

 

Applications:

•       Method of isolation and purification of islet β cells specific exosomes from serum/plasma

 

Advantages:

•       Diagnostic platform for early prognosis and diagnosis of metabolic diseases

 

Stage of Development:

•       Small size human sample data

 

Intellectual Property:        

Pending PCT application PCT/US2016/056752

 

Reference Media:

under review

       

Desired Partnerships:

License; Co-development

 

Docket #: 15-7302

 

 

 

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Patent Information:
Category(s):
Diagnostics
For Information, Contact:
Linara Axanova
Associate Director, PSOM Licensing Group
University of Pennsylvania
axanova@upenn.edu
Inventors:
Prashanth Vallabhajosyula
Keywords: