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A pouch-based cassette for bio-detection with timer-based actuator

Description:

Brief Description: Bio-detection cassette with automated actuator for self-contained immunoassay devices and lab-on-a-chip assays

 

Technology:

 

The Bau lab has developed a device that sequentially delivers multiple reagents into a microfluidics based lab-on-a-chip system.  Protrusions on a rotating wheel sequentially press plastic balls onto flexible diaphragms, capping chambers storing reagents and/or wash solutions.  In an alternative embodiment of the device, a pouching actuator is controlled by a spring-driven mechanical timer.  The actuator consists of a timing dial, actuation disc, ball-holding plate, cassette socket and platform, and timer spring box.  Delivery sequence is determined by the number and relative position of balls and protrusions on the holding plate and actuation disc, respectively.

On top, immunoassay chip with integrated actuator, and on bottom, schematic diagram of mechanically activated actuator.

 

Advantages:

·         Portable, handheld platform

·         Fully integrated, automatic sample preparation, target purification, and amplification

·         Rapid analysis time

·         Low cost

·         Reusable or disposable timer-based actuator

·         Diagnostic performance on par with existing lab-based tests

 

Applications:

·         Point-of-care diagnostics

·         Lab-on-a-chip

·         Immunoassays

 

Stage of Development:

·         Proof-of-concept prototype developed with demonstrated feasibility of molecular marker detection in oral fluid

 

Intellectual Property:

USSN 8,697,007

USSN 8,691,592

 

Reference Media:

Qiu X. et al.  Sensors and Actuators B: Chemical, 2011, 160(1), p. 1529-1535.

Liu C. et al.  Lab on a Chip, 2009, 9(6), p. 768-776.

 

Desired Partnerships:

1.    License

2.    Co-development

 

TLO:

            Sarah Johnson

            johnsa@upenn.edu

            215-746-7253

 

Download PDF

Docket #: U4838, T4403

 


Patent Information:
For Information, Contact:
Joshua Jeanson
Associate Director, SEAS/SAS Licensing Group
University of Pennsylvania
jeanson@upenn.edu
Inventors:
Haim Bau
Changchun Liu
Keywords: