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LEADER SEQUENCE TO BOOST GENE EXPRESSION

Description:
The inventors have designed a 28-codon leader tag that, when incorporated onto the 5’ end of a gene of interest, significantly improves gene expression efficiency and protein production in recombinant expression systems.  The leader sequence boosts protein production by introducing weak secondary structure into the mRNA, permitting more efficient binding near the ribosomal binding site.

IP Status:
Issued US patent:  US 12/984,251

References:
Kudla, G., et al., Science. 2009 Apr 10;324(5924):255-8


Patent Information:
For Information, Contact:
Pamela Beatrice
Director, SEAS/SAS Licensing Group
University of Pennsylvania
215-573-4513
beatricp@upenn.edu
Inventors:
Joshua Plotkin
Keywords: