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TRANSCRIPTOME IN VIVO ANALYSIS (TIVA)

Description:
TIVA is a novel platform that enables spatial and temporal analysis of the transcriptome in single or multiple cells from a heterogeneous population. TIVA be combined with numerous in vivo and in vitro functional analysis techniques which are not supported by current RNA isolation methodologies. Potential applications include: (1)temporal RNA transcriptome analysis within a cell; (2)spatial RNA analysis within a cell (e.g. dendrites of neurons or apical region of a stromal cell); (3)rapid RNA capture from individual cells within the same tissue; (4)analysis of RNA in cells that are connected or in communication with one another; (5)measurement of in vivo rates of RNA accumulation or degradation; (6) use with other in vivo techniques, such as live-imaging or electrophysiology.

IP Status:
Pending US rights

References:
Lovatt, D. et al. Nat Methods. 2014 Feb;11(2):190-6


Patent Information:
For Information, Contact:
Linara Axanova
Associate Director, PSOM Licensing Group
University of Pennsylvania
axanova@upenn.edu
Inventors:
James Eberwine
Keywords: