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MODULATORS OF BROWN ADIPOSE TISSUE THERMOGENESIS

Description:

Brown adipose tissue (BAT) is a critical site of heat production in mammals. BAT consumes lipid to generate heat, thus modulating BAT function can increase energy expenditure to reduce body weight and improve systemic metabolism. In all mammals, body temperature and metabolic activity are controlled by a circadian rhythm and Rev-Erbα has been demonstrated to link circadian and thermogenic networks to regulate activity. Pharmacological targeting of the nuclear receptor Rev-Erbα is a novel strategy to boost BAT thermogenesis for the prevention and treatment of obesity and we are seeking research and development partners to collaborate with us to identify and validate new compositions useful for modulating Rev-Erbα.

IP Status:
Pending US rights

References:
Gerhart-Hines, Z. et al. Nature. 2013 Nov 21; 503(7476): 410-3.

 

Docket # Z6752


Patent Information:
For Information, Contact:
Viviane Martin
Director, PSOM Licensing Group
University of Pennsylvania
martinv@upenn.edu
Inventors:
Mitchell Lazar
Keywords: