Available Technologies

Browse Penn-owned technologies available for licensing.

HOME SEARCH RSS FEED

Human monoclonal autoantibodies to ADAMTS13 and uses thereof

Description:

Brief Description:

Human anti-ADAMTS13 antibodies cloned from patients with acquired thrombotic thromobocytopenia purpura (TTP) for use in targeted therapies, and generation of animal models that recapitulate pathologic features of TPP.

 

Technology:

Thrombotic thrombocytopenic purpura (TTP) is a rare but life-threatening blood disorder where blood clots form throughout the body to block the flow of oxygen-rich blood to major organs. Acquired TTP is caused by the generation of autoantibodies to the ADAMTS13 metalloprotease enzyme to block its activity and cause inappropriate platelet clotting. First-line treatment involves plasmapheresis to lower autoantibody levels and replenish ADAMTS13 through transfusion of donor plasma. However, treatment is nonspecific, expensive, and not always effective. Additionally, the development of therapies has been limited by the lack of animal models specific to the human autoantibodies.

 

Dr. Donald Siegel and colleagues have cloned and sequenced human monoclonal ADAMTS13 autoantibodies from patients with acquired TTP. They have identified the specific sequences that block ADAMTS13 function to cause TTP pathogenesis. Using these recombinant human ADAMTS13 autoantibody sequences, a novel TTP murine model has been generated that recapitulates key pathologic features, and new therapeutics, such as anti-idiotypic antibodies, are currently being developed for the targeted TTP treatment, which improves specificity over current treatment methods.

 

Caption:

Inhibition of murine ADAMTS13 activity by injection of DNA encoding human anti- ADAMTS13, which was identified autoantibodies of TPP patients. (Ostertag et al. Transfusion, 2016, 56(7) - 1775).

 

Applications:

·         Development of more effective, targeted therapies for TTP, such as anti-idiotypic agents

·         Generation of improved animal models of TTP that permits testing of therapeutics targeting human antibody/ADAMTS13 interaction

 

Advantages:

·         Provides an alternative improved, targeted and cheaper treatment for acquired TTP

·         Improves animal models of TTP for more accurate testing of human therapeutic agents

 

Stage of Development:

·         Human anti-ADAMTS13 antibodies have been sequenced and binding sites identified

·         Pathogenicity of ADAMTS13 autoantibodies established in an animal model

·         Currently developing humanized antibodies from anti-idiotypic antibodies

·         in vivo testing, humanized TRM

 

Intellectual Property:

WIPO Patent Application (WO 2016/164468A3)

 

 Reference Media:

·         Ostertag et al. Transfusion, 2016, 56(7) - 1763.

·         Ostertag et al. Transfusion, 2016, 56(7) - 1775.

  

Desired Partnerships:

License

Co-development

 

TLO:

Neal Lemon

nlemon@upenn.edu

215-746-8108

 

Docket # 15-7389


Patent Information:
For Information, Contact:
Neal Lemon
Associate Director, PSOM Licensing Group
University of Pennsylvania
nlemon@upenn.edu
Inventors:
Eric Ostertag
Donald Siegel
X. Long Zheng
Keywords: