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DIAGNOSTICS AND THERAPEUTICS FOR UPPER AIRWAY AND SINUS INFECTIONS

Description:
Severe cases of chronic rhinosinusitis often require surgery to open the sinuses and allow more effective draining and subsequent irrigation to prevent recurrent infection.  In some of these surgical cases; however, the initial surgery is ineffective and the patient may need to undergo subsequent more aggressive surgeries to more fully open the sinus cavities.  The investigators have now discovered that the nasal epithelium contains specific bitter taste receptors.  Importantly, they have also demonstrated that genotype of a specific bitter taste receptor found in the nasal epithelium is very predictive in stratifying rhinosinusitis patients that would benefit from surgery versus those who would not.  In addition, the inventors have demonstrated that stimulation of this bitter taste receptor causes release of an antimicrobial peptide that they proceeded to functionally characterize.  Therefore, in addition to the possible diagnostic applications of this technology, the invention may also be utilized to develop a novel therapeutic for more rapidly clearing infections of the sinuses and upper respiratory tract.

IP Status:
Pending worldwide rights

References:
J Clin Invest. 2014 Feb 17. pii: 72094.
Int Forum Allergy Rhinol. 2013 Dec 2.
Int Forum Allergy Rhinol. 2013 Mar; 3(3):184-7.


Patent Information:
For Information, Contact:
Jeffrey James
TLO
University of Pennsylvania
jeffja@upenn.edu
Inventors:
Noam Cohen
Robert Lee
Keywords: