Available Technologies

Browse Penn-owned technologies available for licensing.

HOME SEARCH RSS FEED

TISSUE SPECIFIC CIRCULATING EPITHELIAL CELLS AS BIOMARKERS FOR CANCER

Description:

The present invention provides a novel method of cancer and cancer metastases detection by identifying and characterizing the origin of circulating epithelial cells (CECs) using tissue-specific markers, such as the pancreas-specific biomarker Pdx-1.  The positive predictive value of Pdx-1 as a marker for circulating pancreatic cells exceeds 90% while the negative predictive value is close to 100%. The number of tissue specific CECs is highly correlated with the cancer progression. This method presents a valuable, minimally-invasive, specific and sensitive tool for cancer diagnosis and management.

IP Status:
Pending worldwide rights

References:
Rhim, A. et al., Cell. 2012 Jan 20;148(1-2):349-61

Docket # X5905


Patent Information:
For Information, Contact:
Viviane Martin
Director, PSOM Licensing Group
University of Pennsylvania
martinv@upenn.edu
Inventors:
Andrew Rhim
Ben Stanger
Keywords: