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Imaging-Based Early Diagnostic and Prognostic for Osteoporosis and Hip Fracture Risk

Description:

High-resolution MRI and CT images analysis software evaluating 3D bone structure and allowing for accurate assessment of (i) bone strength and health, (ii) risk for osteoporosis development, and (iii) risk for hip fracture.

 

Inventors

Chamith S. Rajapakse, Ph.D.

Gregory Chang, M.D.

 

Problem

Osteoporosis affects 50 million Americans and over 200 million people worldwide. It leads to reduced bone strength and increased risk of fracture. Hip fracture in particular is a devastating event with 50% of sufferers losing ability to walk and 20% of suffers dying from it. Over 2 million fractures and 300,000 hip fractures occur annually in the U.S. resulting in $20 billion and $12B in annual healthcare expenses, respectively. Currently, greater than 50% of the individuals with osteoporosis are not detected by bone density testing, the standard-of-care diagnostic test. More accurate and earlier diagnosis is needed and could lead to earlier treatment and the prevention of fractures, saving healthcare costs. 

 

Solution

Dr. Rajapakse and Dr. Chang have developed a software applied to high resolution MRI or CT images of bone microstructure for detailed evaluation of the mechanical strength of the bone. It allows for simulation of various loading conditions, takes into account shape, geometry and distribution of the trabecular building blocks during stress to describe mechanical integrity and accurately determines osteoporosis development and hip fracture risk.

 

 

Applications

• Diagnosis and prognosis of osteoporosis and bone pathologies

• Driver for early treatment for patients with high risk

• Monitoring of disease progression and therapy response

 

Advantages

• Can be used with images from standard clinical MRI or CT machines

• More accurate prediction of osteoporosis development and hip fracture than DEXA

• Earlier detection and treatment of bone loss, leading to lower healthcare costs

• More accurate monitoring of bone loss and treatment effectiveness

• Early screening for predisposed patients (with osteoporosis, family history, metastatic cancer, diabetes, renal diseases)

 

Stage of Development

• Data from ~1000 patients

• Validation data from cadaver bone exposed to mechanical stress

 

Intellectual Property

• Provisional Pending

 

Desired Partnerships

• License

• Co-development

 

Reference Media

Chang et al . Radiology, 2014 272:464

Rajapakse et al. Radiology, 2016, 283 (3): 854

Agten et al. Radiology, 2017, 285(2): 506

 

Docket #: 17-8291


Patent Information:
For Information, Contact:
Linara Axanova
Associate Director, PSOM Licensing Group
University of Pennsylvania
axanova@upenn.edu
Inventors:
Chamith Rajapakse
Gregory Chang
Keywords: