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2D Metal Carbides and Nitrides (MXenes) Electrodes

Description:

 

Problem

Current implantable devices for recording and stimulating electrical activity in the body are fabricated with metal based components. Which pose issues for long term implantation and functionality, including scarring, inflammation, degradation and fatigue. Furthermore, the physical properties of metals are typically inadequate to achieve good quality recording and stimulation performance.

 

Solution

MXene’s offer a unique combination of electrical conductivity, strength, flexibility and volumetric capacitance (300-400 F/cm3). Furthermore, by varying processing parameters, the MXenes are >90% transparent. The electrochemical impedance of MXene neural sensors measured at 1 kHz is 4 times smaller than that of gold electrodes of the same size. When used for recording of neural signal in vivo, this reduction in impedance significantly suppresses noise from electrical interference (> 400-fold reduction compared to gold electrodes) and from electronic noise in the electrode itself (50% less than gold).

 

The MXene ECoG electrodes were tested in vivo in an anesthetized rat, where they were placed on the exposed cortex, showing significantly reduced baseline noise compared to gold electrodes of the same size. Excitingly, penetrating MXene depth electrodes recorded unit activity (individual neuron spiking activity), which was not detected on the gold contacts. (Fig.1A & 1B).

 

 

Applications

• $1,054 million (2015) Global Medical Electrodes Market, reaching $1,328 million by 2022

• Clinical applications in neurodegenerative disease; epilepsy and cardiovascular disorders including as         Pacemaker electrodes (Cardiovascular), DBS electrodes (ie. Parkinson’s Disease), BMI electrodes , intracranial EEG electrodes, and penetrating intracortic electrode arrays.

• Transparent biological sensors for imaging and intracellular recordings.

 

Advantages

• Significant suppression of electrical interference and electronic noise in the electrode.

• Better electrical conductivity, strength, flexibility and volumetric capacitance.

• Better optical properties than metals including tunable optical transparency (>90 %)

• Unique ability to record single unit neuron activity.

 

Stage of Development

• Fabrication of two types of electrodes for measuring ECoG and individual neurons

• Characterization of electrochemical impedance

• Enhanced performance during in vivo testing

 

Intellectual Property

1. US Provisional Patent Application

Filed Sept. 2017 

 

Reference Media

Anasori, B., Lukatskaya, M.R., & Gogotsi, Y. (2017). 2D Metal carbides and nitrides (MXenes) for energy storage. Nature Reviews Materials, 2, 16098-17.

 

Docket # 17-8285


Patent Information:
For Information, Contact:
Neal Lemon
Associate Director, PSOM Licensing Group
University of Pennsylvania
nlemon@upenn.edu
Inventors:
Flavia Vitale
Brian Litt
Keywords: