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Topical Treatment for Autoimmune Disorders

Description:

Treatment method for autoimmune diseases such as diabetes, multiple sclerosis, atherosclerosis, and rheumatoid arthritis using skin application of a vitamin D analog where topical treatment leads to systemic immunoregulation.   

 

Inventor

Taku Kambayashi, M.D, Ph.D.

 

Problem

Immunomodulatory drugs are typically administered systemically and often lead to severe side effects. Moreover, intravenous injections of such drugs are burdensome for patients and drive additional cost and risks. Whenever treatment involves biological compounds it further increases the cost and requires special storage, shipping, and handling. 

 

Solution

Many inflammatory diseases are mediated by inappropriately activated T cells. Regulatory T cells (Tregs), on the other hand, limit such inappropriate T cell activation, and prevent inflammatory diseases. Dr. Kambayashi has discovered that topical administration of a vitamin D3 analog MC903 leads to the release of keratinocyte-derived thymic stromal lymphopoietin (TSLP) by skin cells into circulation, which then systemically increases the number of Tregs. He further has shown that this Treg expansion leads to attenuation of inflammatory diseases such as type I and type II diabetes, multiple sclerosis, atherosclerosis, and rheumatoid arthritis in mouse models. Thus use of transdermal patch delivering MC903 provides a promising approach for treatment autoimmune and inflammatory diseases.

 

 

 

Advantages

• Topical treatment producing systemic effect

• MC903 has limited systemic absorption and half-life preventing systemic toxicities

• MC903 is used for psoriasis treatment (expired patent, available generics)

 

 

Application

• Patch or other method of transdermal delivery

 

 

Stage of Development

Mouse models of type I diabetes (NOD mouse)

Multiple sclerosis (EAE mouse model)

Atherosclerosis (ApoE KO mouse model)

Rheumatoid arthritis (serum-induced arthritis)

 

 

Intellectual Property

US2018/0064732

JP2018513849A

 

Reference Media

Leichner et al. J Autoimmun, 2017 May, 79: 39-52.

 

Desired partnerships

• License

Co-development

 

 

Download PDF

 

Docket # 15-7433

 


Patent Information:
For Information, Contact:
Linara Axanova
Associate Director, PSOM Licensing Group
University of Pennsylvania
axanova@upenn.edu
Inventors:
Taku Kambayashi
Keywords: