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Critical Role of a kinase in breast and colon cancer pathogenesis


The present invention discloses a serine/threonine kinase found to play a critical role in the pathogenesis of breast and colon cancers and is a potential diagnostic, prognostic, and therapeutic target.



Lewis Chodosh, MD, PhD, Department of Cancer Biology



Results from clinical studies indicate that early full term births result in permanent change of breast tissue, decreasing a women’s risk of developing breast cancer. Moreover, aberrant expression or mutations of protein kinases are linked to the pathogenesis of cancer in humans. A protein or small molecule that provides a molecular target in this pathway would provide significant diagnostic and therapeutic benefit to numerous cancer patients.



This invention relates to the discovery of a serine/threonine kinase, Pregnancy-Up-regulated Nonubiquitous CaM Kinase (PNCK), which is markedly over expressed in a variety of human breast cancers and directly correlated to the tumor grade of ovarian cancers. Also, PNCK was found to be decreased in human colon carcinomas and inversely correlated with colon cancer tumor grade. 



• Use to diagnose breast cancer

• Use to diagnose human colon carcinomas

• Use of PNCK or PNCK nucleotide sequence for drug screening 


Stage of Development

In-vivo murine data 

Intellectual Property

USSN 7,041,495

USSN 7,741,111  


Reference Media

Gardner et al. Cancer Res. 2000, 60(19) - 5571-7


Desired partnerships

• License



Download PDF


Docket # O2740 

Patent Information:
For Information, Contact:
Linara Axanova
Associate Director, PSOM Licensing Group
University of Pennsylvania
Lewis Chodosh