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Multi-channel Photodynamic Therapy Light Dosimetry System

Description:

 

PDT dosimetry instrument and system capable of measuring light fluency rate, reactive oxygen species and photosensitizer concentration simultaneously at multiple sites and allowing to adjust the PDT dose in real-time during treatment.

 

Technology

 

Photodynamic therapy (PDT) is a treatment modality that is often used during surgeries to eradicate remaining cancer cells. PDT utilizes a drug - photosensitizer (PS) which becomes activated when exposed to a specific wavelength of light and produces reactive oxygen species (ROS) that destroys adjacent cancer cells. PDT has been approved by FDA for treatment of several types of cancers and is being tested in a number of clinical trials for treatment of brain, skin, prostate, cervix, and peritoneal cavity malignancies.

 

Dosing PDT is a critical aspect of the treatment - inadequate treatment dose may lead to residual cancer cells, while excessive doses may result in severe damage to the tissue leading to burns, swelling, pain, and scarring. Effective PDT dose depends on multiple factors such as local PS dose, tissue optical properties, oxygenation level, photobleaching, absorption and scattering of light, hemoglobin levels, damage to the tissue by surgery which are all dynamic. In addition, there is significant inter- and intra-patient variability in the PS pharmacokinetics, tissue optical properties, and local tissue oxygenation. Thus, there is a critical need for reliable dose metrics which would allow to deliver optimum PDT dose to treated tissues.

 

Dr. Timothy Zhu at the Medical School of the University of Pennsylvania have developed PDT device and system which permits to measure light fluence rate, PS concentration, and tumor blood flow. This approach allows to calculate local ROS concentration for accurate prediction of PDT outcome and dose adjustment. Inventor demonstrated the utility of the device in clinical settings using photofrin-mediated PDT assessing ROS levels simultaneously at multiple sites in real time.

 

 

Applications

 

•       Measurement and adjustment of PDT dose at up to 16 sites

 

Advantages

 

•       Improved PDT treatment outcome through real-time adjustment of PDT dose

•       Simultaneous reading from multiple channels (up to 16)

•       Entire spectrum light measurements

•       Assessment of local light fluency, PS concentration and created ROS 

 

Stage of Development

 

•       Clinical human data on photofrin-mediated PDT in pleural cavity

•       Tissue simulating phantoms and animal data

 

Intellectual Property

 

Pending Provisional Application

 

Reference Media

 

Ong, YH et al.  Phys Med Biol. 2017 Dec 29;63(1):015031.

Qiu, H et al.  Photochem Photobiol. 2017 Jul;93(4):1115-1122.

Sheng, T et al.  Proc SPIE Int Soc Opt Eng. 2019 Feb;10860. 

Sheng, T et al.  Proc SPIE Int Soc Opt Eng. 2019 Feb;10861.

Ony, YH et al.  Proc SPIE Int Soc Opt Eng. 2018 Feb;10476.

 

Docket # 19-8830

 

Download pdf


Patent Information:
For Information, Contact:
Linara Axanova
Associate Director, PSOM Licensing Group
University of Pennsylvania
axanova@upenn.edu
Inventors:
Timothy Zhu
Arjun Yodh
Keywords: