Mouse PancChip

Description:

TechID: Q3255

Despite continuous efforts in diabetes research, tools for the treatment of diabetes have not changed significantly. The identification of endocrine precursor cells and factors that regulate the development and differentiation of beta-cells is still a major hurdle.

Researchers at the University of Pennsylvania have assembled a non-redundant pancreatic mouse cDNA clone set which represents the vast proportion of the pancreatic and islet gene expression profile. This clone set represents 13,000 non-redundant clones which were thoroughly characterized by sequence analysis, expression analysis and database mining. Since current microarrays are not focused on the pancreas, this clone set could be a useful tool in diabetes and pancreatic cancer research.

Applications

• Islet transplantation
• Stem cell therapy
• Profiles of gene expression
• Target discovery

Advantages

• Provides a snapshot of the pancreas - no pancreas-specific microarrays are currently available