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A pouch-based cassette for bio-detection with timer-based actuator

Description:

Bio-detection cassette with automated actuator for self-contained immunoassay devices and lab-on-a-chip assays

 

Technology Overview: 

The Bau Lab has developed a device that sequentially delivers multiple reagents into a microfluidics based lab-on-a-chip system.  Protrusions on a rotating wheel sequentially press plastic balls onto flexible diaphragms, capping chambers storing reagents and/or wash solutions.  In an alternative embodiment of the device, a pouching actuator is controlled by a spring-driven mechanical timer.  The actuator consists of a timing dial, actuation disc, ball-holding plate, cassette socket and platform, and timer spring box.  Delivery sequence is determined by the number and relative position of balls and protrusions on the holding plate and actuation disc, respectively.

 

Immunoassay chip with integrated actuator
 

Schematic diagram of mechanically activated actuator

 

Advantages: 

  • Portable, handheld platform
  • Fully integrated, automatic sample preparation, target purification, and amplification
  • Rapid analysis time
  • Low cost
  • Reusable or disposable timer-based actuator
  • Diagnostic performance on par with existing lab-based tests


Applications: 

  • Point-of-care diagnostics
  • Lab-on-a-chip
  • Immunoassays

Stage of Development: 

Proof-of-concept prototype developed with demonstrated feasibility of molecular marker detection in oral fluid 

 

Intellectual Property: 

Reference Media: 

Desired Partnerships: 

  • License
  • Co-development

Docket # U4838, T4403

 

Download PDF

 


Patent Information:
For Information, Contact:
Joshua Jeanson
Associate Director, SEAS/SAS Licensing Group
University of Pennsylvania
jeanson@upenn.edu
Inventors:
Haim Bau
Changchun Liu
Keywords: