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Hydrogel-based tissue engineering scaffold that supports angiogenesis and rapid vascularization

Description:

Bioactive hydrogels microengineered from step-growth derived PEG-peptide macromers

 

Problem: 

Angiogenesis is the process by which new capillary vessels form from existing vasculature, and it is involved in wound healing and embryonic development. The dysregulation of angiogenesis has been implicated in cancer, inflammation, and ischemic diseases. 

 

Examining the physical process of angiogenesis requires experimental systems that can readily manipulate the formation of capillary vessels.  A severe limitation in expanding the field of engineered biomaterials is the lack of adequate vasculature for nutrient delivery and the elimination of metabolic waste products. Synthetic hydrogels based on polyethylene glycol (PEG) have historically used multi-arm precursors that are challenging and expensive to synthesize and purify.

 

Solution: 

The Chen Lab has designed an inexpensive, robust synthetic route to bioactive PEG-based hydrogels that can be implemented as scaffolds with inherent pathways for the formation of new vasculature. Because of PEG’s neutral charge, hydrophilicity, and resistance to protein adsorption, it is biocompatible for in vitro and in vivo experiments. 

 

The researchers implemented a step-growth polymerization of bis-cysteine matrix metalloprotease (MMP)-sensitive peptides and PEG-diacrylate to generate high molecular weight photoactive polymers, followed by crosslinking into hydrogels via radical-mediated photopolymerization. As the first 3D biomimetic model to reconstitute angiogenic sprouting, this system can elucidate the molecular mechanisms underlying vascularization and wound healing, as well as aid in the design of materials for tissue engineering applications.

 

Inventor:

Christopher Chen, Professor of Bioengineering

 

Characterization of late sprouts via confocal immunofluorescence images shown in z-projection.  On left, mature sprout stained for podocalyxin, with blue arrow marking cell invading out from stalk, in cross-sections of tip cell.  On right, mature sprout stained for laminin, with blue arrow marking stalk cell filopodia. Adapted from Miller et al, 2010.

 

Advantages: 

  • Inexpensive, readily available PEG precursors
  • Straightforward chemical synthesis
  • Biocompatible material

Applications: 

  • Tissue engineering
  • Wound healing
  • Modulation of angiogenic sprouting
  • Promote vascularization in synthetic materials

Stage of Development: 

In vitro testing

 

Intellectual Property:

UP application (US20120202263 A1)

 

Reference Media: 

 

Desired Partnerships: 

  • License
  • Co-development

 

Docket # W5599 

 

 

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Patent Information:
Category(s):
Materials
For Information, Contact:
Qishui Chen
Licensing Officer, SEAS/SAS Licensing Group
University of Pennsylvania
215-898-9591
qchen1@upenn.edu
Inventors:
Christopher Chen
Keywords: