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Site-specific bioconjugation of native immunoglobulins
Method for covalent cross-linking of antibodies to surfaces for immunoassays and targeted drug delivery Technology Overview: The Tsourkas Lab has designed a facile method for the site-specific bioconjugation of native immunoglobulins (IgGs). The researchers have developed novel photoreactive Protein Z variants that allow for the introduction of...
Published: 3/20/2020   |   Inventor(s): Andrew Tsourkas
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Research Tools & Reagents, Therapeutics & Vaccines, Imaging
Single step protein purification and site-specific bioconjugation
Sortase-mediated expressed protein ligation and bioconjugation for molecular imaging and targeted therapeutics Technology Overview: The Tsourkas Lab has developed a novel conjugation technique that allows any single-chain recombinant protein to be site-specifically modified at the C-terminus during protein expression and purification procedures....
Published: 3/20/2020   |   Inventor(s): Andrew Tsourkas
Keywords(s):  
Category(s): Chemical Processes and Synthesis, Research Tools & Reagents, Imaging
Hyperpolarized gas delivery to subject in MRI scanner for enhanced pulmonary diagnostics and disease progression monitoring
Device for the optimal mixing and delivery of MRI gaseous contrast agents Problem: Gaseous contrast agents, and more specifically, hyperpolarized (HP) noble gases, such as helium-3 and xenon-129, are used for investigational imaging of respiratory gas in lungs by MRI for the purpose of assessing regional lung function. The ultimate goals of such...
Published: 3/20/2020   |   Inventor(s): Kiarash Emami, Stephen Kadlecek
Keywords(s):  
Category(s): Diagnostics, Imaging, Medical Devices
Antibodies for Targeting CAR-T Cells to Neuroendocrine Tumors
Technology Overview: Neuroendocrine tumors (NETs) pose serious threats to patients’ well-being as malignant diseases, and most patients with metastatic NETs succumb to the disease. Using Sequential Tumor-related Antibody and antigen Retrieving (STAR) technology Dr. Xianxin Hua, MD, PhD at the University of Pennsylvania Medical School and his...
Published: 3/20/2020   |   Inventor(s): Xianxin Hua
Keywords(s):  
Category(s): Diagnostics, Imaging, Therapeutics & Vaccines
Novel Choline Kinase inhibitors for cancer imaging and therapy
Novel compounds allowing for optical detection and targeting of Choline Kinases for cancer treatment. Problem: Choline Kinase (ChoK) deregulation is associated with oncogenesis and tumor progression in a number of human cancers, including glioblastoma, breast, and lung cancers. In breast cancer, elevated ChoK activity is correlated with histological...
Published: 3/19/2020   |   Inventor(s): Edward Delikatny
Keywords(s): Oncology
Category(s): Diagnostics, Therapeutics & Vaccines, Imaging
A flow cell for electron microscope imaging with multiple flow streams
Nanoaquarium: nanofluidic platform for in situ TEM imaging of fluid-mediated samples Problem: Many nanoscale phenomena occur in liquid media, including nanoparticle and colloidal formation, nanowire liquid phase growth, electrochemical deposition and etching for batteries, and biological interactions. Real-time, in situ transmission electron...
Published: 3/18/2020   |   Inventor(s): Haim Bau
Keywords(s):  
Category(s): Imaging, Research Tools & Reagents
Fabricating specialized oleosins: From surfactants to drug delivery to imaging
Technology Overview: The Hammer and Lee Labs have developed a method to produce oleosins and functionalized oleosins for a wide variety of applications from surfactants to a drug delivery vehicle to cancer cells. E. Coli can be can be transformed to fabricate oleosin or oleosin with additional molecules, including antibodies and GFP. Problem:...
Published: 3/18/2020   |   Inventor(s): Daniel Hammer, Daeyeon Lee
Keywords(s): Nanotechnology
Category(s): Materials, Imaging
Classifying high-frequency oscillations in physiological recordings
Method for automatic and unsupervised classification of high-frequency oscillations in physiological recordings. Problem: Automatic detection and classification of high frequency oscillations (HFO) data for use in clinical diagnosis and therapy has been limited. Currently, researchers visually inspect for high frequency oscillations. Solution:...
Published: 3/18/2020   |   Inventor(s): Brian Litt
Keywords(s): Bioengineering, Neurodegenerative Diseases
Category(s): IT & Communication & Networking, Research Tools & Reagents, Imaging, Medical Devices
Nanoparticle-oligonucleotide hybrid structures for biosensors, bio-imaging, and targeted delivery
Self-assembled hybrid structures of DNA block-copolymers and nanoparticles with enhanced DNA binding and high selectivity Technology Overview: Researchers in the Park Lab have developed a method that exploits the self-assembling property of DNA-polystyrene block copolymers to synthesize hybrid nanoparticles. These hybrid structures encapsulate...
Published: 3/17/2020   |   Inventor(s): So-Jung Park
Keywords(s): Nanotechnology
Category(s): Research Tools & Reagents, Imaging
Method for near-field optical imaging
Phase-less optical near-field tomography with sub-wavelength resolution in three dimensions Technology Overview: This invention embodies a system and method for optically imaging a sample at nanometer resolution using a position-controlled light scattered in the near field of a sample. The extinguished power from an incident field, which illuminates...
Published: 3/17/2020   |   Inventor(s): John Schotland
Keywords(s):  
Category(s): Imaging, Software & Data & Algorithms & Apps, Research Tools & Reagents
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