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Device to treat pain and loss of feeling from diabetic neuropathy

Implantable foot device to restore feeling and reduce pain associated with diabetic nerve complications. Problem: Sixty to seventy percent of the 400 million diabetes patients worldwide suffer from nerve complications like distal sensory polyneuropathy (DSP), characterized by foot pain and loss of feeling. If left unchecked DSP progresses to severe...

Published: 3/4/2021

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Gum-health promoting smart dental implant system

Dental implant that inhibits plaque accumulation and gingival tissue inflammation by photobiomodulation therapy delivered by embedded light-emitting diodes (LEDs) powered by electricity generated from the patient’s own oral motion. Problem: More than half of adults will lose one or more teeth in their lifetime. When a patient loses a tooth the...

Published: 2/9/2021

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Device for MRI scanner intra-bore disinfection

Magnetic field-safe device for rapid disinfection of MRI bore and other types of scanners (CT, PET, PET-MR, SPECT) that is effective against COVID19, MRSA and other pathogens.</rss.brief Problem: With the advent of COVID-19, renewed emphasis has been placed on disinfecting surfaces in the medical environment. Disinfecting the MRI scanner bore...

Published: 6/23/2020

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Functional nerve guidance conduit for the rapid treatment of peripheral nerve injuries

A collagen-based nerve guidance conduit containing functional Schwann cell precursor-like cells derived from stem cells for the rapid treatment of peripheral nerve injuries. Technology Overview: A peripheral nerve injury (PNI) occurs in approximately 3% of all trauma patients. While treatment options for PNIs have improved with advances in microsurgical...

Published: 5/5/2020

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Virtual reality for low vision patients

Problem: Low vision is a significant public health problem affecting more than 3.5 million people in the US alone compromising an individuals’ sense of independence, ability to carry out daily life activities, and safety. Without retinal input, the downstream visual pathways also deteriorate. Thus, enhancement of the remaining visual function...

Published: 4/1/2020

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Electrodes for long term in-vivo implantation and in-vitro use

Problem: Implantable devices for use in the body of a subject, such as neural prosthetic systems, have had limited success due to the challenges presented by the environment the devices are exposed to.Long-term interaction with the implantable device and the body takes a toll on these implantable devices. Impedance degradation, scar tissue formation,...

Published: 3/23/2020

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New device for aortic repair and replacement

Problem: Professors from Penn Cardiothoracic Surgery have designed a single device that is able to replace the aortic valve and repair the ascending aorta in one procedure. Patients with only aortic valve disease often undergo a minimally-invasive surgery called transcatheter aortic valve Implantation/replacement (TAVI). But for patients who also...

Published: 3/20/2020

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Hyperpolarized gas delivery to subject in MRI scanner for enhanced pulmonary diagnostics and disease progression monitoring

Device for the optimal mixing and delivery of MRI gaseous contrast agents Problem: Gaseous contrast agents, and more specifically, hyperpolarized (HP) noble gases, such as helium-3 and xenon-129, are used for investigational imaging of respiratory gas in lungs by MRI for the purpose of assessing regional lung function. The ultimate goals of such...

Published: 3/20/2020

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High spatial and temporal resolution mapping of brain activity using flexible multiplexed electrode arrays with long term stability and safety

Flexible foldable actively multiplexed high density electrode array for mapping brain activity in-vivo Problem: Electrode arrays for recording and stimulating the brain are used throughout clinical medicine and basic neuroscience research, but are unable to sample large areas of the brain while maintaining high spatial resolution because of the need...

Published: 3/19/2020

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A disposable self-heating cartridge for point-of-care molecular diagnostics

A water-activated, self-heating, instrument-free microfluidic diagnostic cartridge Problem: Many molecular diagnostic devices require elevated temperatures to carry out biochemical reactions, such as those needed for nucleic acid amplification, including loop-mediated isothermal amplification (LAMP). The temperature is typically regulated with external...

Published: 3/19/2020

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