Available Technologies

Browse Penn-owned technologies available for licensing.

HOME SEARCH RSS FEED

Search Results - Research+Tools+%26+Reagents

151 Results Sort By:

High performance CRISPR-Cas12a system for combinatorial genetic manipulation

CRISPR-Cas12a allowing for simultaneous editing of multiple genes in mammalian cells Problem: CRISPR-based gene editing technique has revolutionized the field of molecular biology. While CRISPR-Cas9-based methods are effectively used for single-gene knockout, multiplex gene editing remains a major challenge. Unlike Cas9, Cas12a can be used for multigene...

Published: 11/5/2020

Inventor(s):

Keywords(s):

Category(s):

Antibody discovery platform for CAR-T cell targeting and drug conjugation

Technology Overview: Screening platform for identification of potent and specific nanobodies for (i) directing CAR-T cells to cancer cells, (ii) drug conjugation, or (iii) tumor imaging or diagnosis. Identification of antibodies capable of mediating CAR-T killing is challenging due to several reasons. First, the antibody has to have certain affinity...

Published: 11/2/2020

Inventor(s):

Keywords(s):

 

Category(s):

Rapid and ultrasensitive profiling of EGFRvIII mutations in cancer and normal tissue

A method to rapidly detect the presence of EGFRvIII mutations in cancers and normal tissue using digital PCR. Problem: Glioblastoma multiforme (GBM) is a devastating brain cancer with poor prognosis. EGFRvIII is a mutation in the Extracellular Growth Factor Receptor that frequently occurs in GBM tumors. Targeting EGFRvIII mutations is an emerging...

Published: 10/5/2020

Inventor(s):

Keywords(s):

Category(s):

Rapid method to design and screen novel lipid nanoparticles for mRNA delivery in vivo

A platform technology to rapidly identify novel lipid nanoparticle (LNP) formulations to carry mRNA-based therapeutics to target organs/cells in vivo. Problem: Messenger RNA (mRNA) has emerged as a promising new class of nucleic acid therapy, with the potential to induce protein production to treat and prevent a range of diseases. While significant...

Published: 5/4/2020

Inventor(s):

Keywords(s):

Category(s):

Site-specific bioconjugation of native immunoglobulins

Method for covalent cross-linking of antibodies to surfaces for immunoassays and targeted drug delivery Technology Overview: The Tsourkas Lab has designed a facile method for the site-specific bioconjugation of native immunoglobulins (IgGs). The researchers have developed novel photoreactive Protein Z variants that allow for the introduction of...

Published: 3/20/2020

Inventor(s):

Keywords(s):

 

Category(s):

Single step protein purification and site-specific bioconjugation

Sortase-mediated expressed protein ligation and bioconjugation for molecular imaging and targeted therapeutics Technology Overview: The Tsourkas Lab has developed a novel conjugation technique that allows any single-chain recombinant protein to be site-specifically modified at the C-terminus during protein expression and purification procedures....

Published: 3/20/2020

Inventor(s):

Keywords(s):

 

Category(s):

New technology for detection of proton therapy beams

Technology Overview: This technology provides a novel proton beam profiling technology with excellent spatial and temporal resolution. Proton radiation therapy is becoming widely adopted for cancer treatment due to its capability of producing maximum dosage within an extremely small area and controlled depth in the tissue. In order to controllably...

Published: 3/20/2020

Inventor(s):

Keywords(s):

 

Category(s):

Fluorinated building blocks for organic synthesis and macromolecule synthesis

Synthesis of trifluoromethylated alkylboron compounds and incorporation into small molecules and macromoleculesProblem: Fluorinated macromolecules are widely utilized in industry, with the most notable example being Teflon, or perfluorotetrafluoroethylene (PTFE). Additionally, methods for incorporating CF3 into small organic molecules are not well developed,...

Published: 3/20/2020

Inventor(s):

Keywords(s):

 

Category(s):

Reusable silicon-based cross-coupling agents for the production of natural products, pharmaceuticals, and other organic materials

Cross-coupling reactions without the generation of waste productsProblem: Catalytic carbon-carbon bond formation based on cross-coupling reactions (CCRs) plays a central role in the production of natural products, pharmaceuticals, agrochemicals, and organic materials. Coupling reactions with organometallic reagents and organic halides facilitate a plethora...

Published: 3/20/2020

Inventor(s):

Keywords(s):

 

Category(s):

High throughput identification of transcriptome wide RNA-protein interactions

RNAase-mediated protein footprint sequencing to reveal protein binding sites on transcriptome-wide scaleTechnology Overview: The Gregory Lab has developed a high-throughput, ribonuclease-mediated protein sequencing approach termed Protein Interaction Profile sequencing (PIP-seq). PIP-seq identifies RNA-protein interaction sites within both unprocessed...

Published: 3/19/2020

Inventor(s):

Keywords(s):

 

Category(s):

1 2 3 4 5 6 7 8 9 10 ...