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Adoptive T cell therapy for cancer using Mutant KRAS-specific T cell receptors for T cell engineering

We have isolated, cloned, and characterized multiple T cell receptors (TCRs) from human donors specific for common mutations in KRAS and restricted to highly prevalent HLA types. These TCRs, protected by a Penn provisional filing, are suitable for T cell engineering for the adoptive immunotherapy of cancer patients of select HLA types and tumors expressing...

Published: 7/8/2021

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Microfluidic device for large-scale production of lipid nanoparticles

​A scalable, parallelized, multi-channel microfluidic device for generating lipid nanoparticles. Problem: Lipid nanoparticles are a promising delivery technology for RNA therapeutics and vaccines. However, there is a lack of formulation strategies that can produce nanoparticles with precisely defined properties that have scalable throughputs ranging...

Published: 7/8/2021

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Efficient and controllable genome editing complex

A split enzyme complex enabling precise gene editing Technology Overview: The ability to target DNA deaminases to specific loci in concert with CRISPR/Cas systems has opened up new frontiers with the potential to transform biology and medicine by allowing for precise genome editing. At the same time, current DNA “base editors” typically...

Published: 6/2/2021

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Mannan-degrading enzymes (MDEs) disrupting bacterial-fungal biofilms for prevention of dental cavities

Enzymes that degrade mannose to prevent the formation of bacterial-fungal biofilms, which cause dental cavities Problem: Dental cavities are among the most common oral diseases among children and adults in the United States, with treatments for this condition exceeding $81 billion annually. Dental cavities occur when the bacteria Streptococcus mutans...

Published: 4/6/2021

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Novel pyrimidine derivatives to treat Alzheimer’s Disease

Brain penetrating compounds as promising therapeutics for treatment of neurodegenerative disorders. Problem: An estimated 6.2 million Americans live with Alzheimer’s Disease (AD), and this number is projected to reach over 13 million by 2050 with societal costs expected to rise to $1.1 trillion. A key feature of AD-affected brain tissue is the...

Published: 3/16/2021

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Small molecule therapeutics for hematologic malignancies

Small molecule inhibitors of a key cancer cell signaling pathway cause hematologic cancer cell death, but have low toxicity towards healthy cells. Technology Overview: Hematologic malignancies begin in blood-forming tissue, like the bone marrow or in the cells of the immune system. Non-Hodgkin lymphoma and leukemia were the 7th and 10th most diagnosed...

Published: 3/9/2021

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Device to treat pain and loss of feeling from diabetic neuropathy

Implantable foot device to restore feeling and reduce pain associated with diabetic nerve complications. Problem: Sixty to seventy percent of the 400 million diabetes patients worldwide suffer from nerve complications like distal sensory polyneuropathy (DSP), characterized by foot pain and loss of feeling. If left unchecked DSP progresses to severe...

Published: 3/4/2021

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Durable and targeted nanoparticle treatment for osteoarthritis

An osteoarthritis treatment comprised of TGFa nanoparticles that penetrate cartilage and persist in the joint. Problem: Osteoarthritis (OA), a degenerative joint disease, is the most common form of arthritis, with over 32 million adults affected in the US alone. Despite its prevalence and debilitating nature, no cure or disease-modifying treatment...

Published: 2/26/2021

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Histone deacetylase and DNA methyltransferase inhibitors for preventative cardiac care and ischemic injury treatment

HDAC and DNMT Inhibitors such as Trichostatin A (TSA) and 5-aza-cytidine are preventative therapies and reduce myocardial infarct volume following cardiac events Technology Overview: Every 40 seconds, someone in the United States has a heart attack. Although several therapeutic options for heart attack recovery exist, ischemic injuries are responsible...

Published: 2/3/2021

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Antibodies for targeting CAR-T cells to acute Myeloid Leukemia cells

Technology Overview: Acute myeloid leukemia (AML) is a major form of acute leukemia in elder adults. The treatment of AML has changed little in the past decades and the overall 5-year survival rate remains very poor in the AML patients. AML relapsed from chemotherapy is highly aggressive with poor prognosis. While adaptive cell therapy via chimeric...

Published: 11/5/2020

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