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Mannan-degrading enzymes (MDEs) disrupting bacterial-fungal biofilms for prevention of dental cavities

Enzymes that degrade mannose to prevent the formation of bacterial-fungal biofilms, which cause dental cavities Problem: Dental cavities are among the most common oral diseases among children and adults in the United States, with treatments for this condition exceeding $81 billion annually. Dental cavities occur when the bacteria Streptococcus mutans...

Published: 4/6/2021

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Novel pyrimidine derivatives to treat Alzheimer’s Disease

Brain penetrating compounds as promising therapeutics for treatment of neurodegenerative disorders. Problem: An estimated 6.2 million Americans live with Alzheimer’s Disease (AD), and this number is projected to reach over 13 million by 2050 with societal costs expected to rise to $1.1 trillion. A key feature of AD-affected brain tissue is the...

Published: 3/16/2021

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Small molecule therapeutics for hematologic malignancies

Small molecule inhibitors of a key cancer cell signaling pathway cause hematologic cancer cell death, but have low toxicity towards healthy cells. Technology Overview: Hematologic malignancies begin in blood-forming tissue, like the bone marrow or in the cells of the immune system. Non-Hodgkin lymphoma and leukemia were the 7th and 10th most diagnosed...

Published: 3/9/2021

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Device to treat pain and loss of feeling from diabetic neuropathy

Implantable foot device to restore feeling and reduce pain associated with diabetic nerve complications. Problem: Sixty to seventy percent of the 400 million diabetes patients worldwide suffer from nerve complications like distal sensory polyneuropathy (DSP), characterized by foot pain and loss of feeling. If left unchecked DSP progresses to severe...

Published: 3/4/2021

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Durable and targeted nanoparticle treatment for osteoarthritis

An osteoarthritis treatment comprised of TGFa nanoparticles that penetrate cartilage and persist in the joint. Problem: Osteoarthritis (OA), a degenerative joint disease, is the most common form of arthritis, with over 32 million adults affected in the US alone. Despite its prevalence and debilitating nature, no cure or disease-modifying treatment...

Published: 2/26/2021

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Histone deacetylase and DNA methyltransferase inhibitors for preventative cardiac care and ischemic injury treatment

HDAC and DNMT Inhibitors such as Trichostatin A (TSA) and 5-aza-cytidine are preventative therapies and reduce myocardial infarct volume following cardiac events Technology Overview: Every 40 seconds, someone in the United States has a heart attack. Although several therapeutic options for heart attack recovery exist, ischemic injuries are responsible...

Published: 2/3/2021

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Antibodies for targeting CAR-T cells to acute Myeloid Leukemia cells

Technology Overview: Acute myeloid leukemia (AML) is a major form of acute leukemia in elder adults. The treatment of AML has changed little in the past decades and the overall 5-year survival rate remains very poor in the AML patients. AML relapsed from chemotherapy is highly aggressive with poor prognosis. While adaptive cell therapy via chimeric...

Published: 11/5/2020

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Antibody discovery platform for CAR-T cell targeting and drug conjugation

Technology Overview: Screening platform for identification of potent and specific nanobodies for (i) directing CAR-T cells to cancer cells, (ii) drug conjugation, or (iii) tumor imaging or diagnosis. Identification of antibodies capable of mediating CAR-T killing is challenging due to several reasons. First, the antibody has to have certain affinity...

Published: 11/2/2020

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Novel inhibitors of ferroptosis

Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases. Problem: Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid-reactive oxygen species. Ferroptosis has been...

Published: 10/16/2020

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Novel AKR1C3 inhibitors in cancer

Inhibitors and tools to block the local formation of steroid hormones in hormone-dependent malignancies of the prostate, breast and endometrium Technology Overview: Standard treatment of care for hormone-dependent tumors utilizes hormone ablative therapies. These agents non-discriminately block the action of estrogens and androgens and have untoward...

Published: 9/29/2020

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