Available Technologies

Browse Penn-owned technologies available for licensing.


Search Results - Therapeutics & Vaccines

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Ultra-fast killing of SARS-CoV-2 and enveloped viruses with a dental irrigation solution
A mixture has been identified that can rapidly deactivate SARS-CoV-2 and similar viruses for use during dental office procedures to prevent viral transmission. Problem: During routine dental procedures, aerosolized droplets containing water, a patient’s saliva and blood, microorganisms and other debris are produced as a result of commonly...
Published: 8/20/2020   |   Inventor(s): Robert Ricciardi, Hyun Koo, Mark Wolff
Keywords(s): Antiviral, COVID-19, Dentistry, Infectious Disease, Surgery
Category(s): Materials, Therapeutics & Vaccines
Targeted drug delivery using red-blood cells for transport
Platform technology for targeted drug delivery using red blood cells for transport. Problem: Drug delivery can often result in up to 99% of the drug being delivered to off-target organs. This can lead to side-effects and toxicities. Current methods that bind drugs to red-blood cells for transport can require modifying the structure of the red...
Published: 6/23/2020   |   Inventor(s): Laura Ferguson, Elizabeth Hood, Carlos Villa, Jacob Brenner, Vladimir Muzykantov
Keywords(s): Acute Lung Injury, Cardiovascular, COVID-19, Drug Delivery, Nanotechnology, Respiratory
Category(s): Therapeutics & Vaccines
Novel AKR1C3 inhibitors in cancer
Inhibitors and tools to block the local formation of steroid hormones in hormone-dependent malignancies of the prostate, breast and endometrium Technology Overview: Standard treatment of care for hormone-dependent tumors utilizes hormone ablative therapies. These agents non-discriminately block the action of estrogens and androgens and have untoward...
Published: 6/5/2020   |   Inventor(s): Trevor Penning
Keywords(s): Gynecology, Men's Health, Oncology
Category(s): Therapeutics & Vaccines
Protein drugs encapsulated in plant cells as low-cost prevention and treatment of lung injury in COVID-19 patients
Use of functional recombinant ACE2 and Angiotensin-(1-7) proteins to improve the clinical course of patients with symptomatic COVID-19 infection. Problem: COVID-19 is associated with high rates of respiratory failure, cardiac injury and death. Patients suffering from COVID-19 generally present with reduced expression of angiotensin converting enzyme...
Published: 6/2/2020   |   Inventor(s): Henry Daniell
Keywords(s): COVID-19
Category(s): Therapeutics & Vaccines
Targeted, efficient, and safe intracellular drug delivery via nanocarriers
Cytosolic drug delivery using DNA-based nanocarriers coated with cell-targeted antibodies. Problem: The ability to deliver drugs intracellularly is critical for the treatment of diseases caused by aberrant processes within the cell. However, current drug delivery methods are ineffective at reaching the cell interior beyond the membranes of the endocytic...
Published: 5/20/2020   |   Inventor(s): Vladimir Muzykantov, Silvia Muro-Galindo
Keywords(s): Drug Delivery
Category(s): Research Tools & Reagents, Therapeutics & Vaccines
Therapeutic antibodies against pathological tau proteins for the treatment of Alzheimer’s Disease (AD)
Two novel monoclonal antibodies were discovered that target pathological conformations of the tau protein. The antibodies were shown in vitro and in vivo to inhibit the spread of pathological tau protein aggregates, which is one of the defining characteristics of AD. Problem: More than 5 million Americans are living with Alzheimer’s disease...
Published: 5/15/2020   |   Inventor(s): Garrett Gibbons, Virginia Lee, Dawn Riddle, John Trojanowski
Category(s): Therapeutics & Vaccines
Anti-RGS12 antibody for treatment of Rheumatoid Arthritis and Osteoporosis
Problem: Rheumatoid Arthritis (RA) affects between 0.5-1% of Americans with symptoms ranging from stiffness to permanent joint damage and disability. There are no effective treatments currently available for RA patients. Solution: To fill this unmet need, the researchers Drs. Yang and Yuan have developed an antibody to block the activity of Regulator...
Published: 5/5/2020   |   Inventor(s): Shicheng Yang, Gongsheng Yuan Yuan
Category(s): Therapeutics & Vaccines
Functional nerve guidance conduit for the rapid treatment of peripheral nerve injuries
A collagen-based nerve guidance conduit containing functional Schwann cell precursor-like cells derived from stem cells for the rapid treatment of peripheral nerve injuries. Technology Overview: A peripheral nerve injury (PNI) occurs in approximately 3% of all trauma patients. While treatment options for PNIs have improved with advances in microsurgical...
Published: 5/5/2020   |   Inventor(s): Anh Le, Qunzhou Zhang
Category(s): Medical Devices, Therapeutics & Vaccines
Treating melanoma with CAR-T cells
gy>Technology Overview: Invasive melanoma is the most lethal and costly skin cancer with over 75,000 new cases and 10,000 deaths per year in the U.S with more than one life claimed every hour. Over the past few years, immunotherapy that target common genetic mutations has dramatically changed the landscape of melanoma treatment but some patients...
Published: 5/5/2020   |   Inventor(s): Todd Ridky
Category(s): Therapeutics & Vaccines
Lipid nanoparticle-based mRNA delivery for CAR T-cell engineering
A library of ionizable lipid nanoparticles (LNPs) was screened for ability to deliver mRNA to T-cells, leading to an optimized LNP formulation for delivery of mRNA to T-cells. This thereby enhances the ability to generate transient chimeric antigen receptor (CAR)-expressing T-cells for cancer immunotherapy.Problem: Chimeric antigen receptor (CAR) T-cells...
Published: 5/4/2020   |   Inventor(s): Margaret Billingsley, Carl June, Nathan Singh, Michael Mitchell
Keywords(s): Bioengineering, COVID-19, Drug Delivery, Immunology, Immunotherapy
Category(s): Therapeutics & Vaccines
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