Available Technologies

Browse Penn-owned technologies available for licensing.


Search Results - Veterinary & Animal Health

7 Results Sort By:
Design of canine antibodies for targeted therapeutics
Methods for generating single chain variable region Fragments (scFvs) for use as targeting agents for the treatment of infectious, inflammatory, and neoplastic diseases in dogs. Problem: Cancer is the leading cause of death in our current canine pet population. Previous studies have found that 45% of dogs aged 10 years or older and 23% of dogs...
Published: 3/11/2020   |   Inventor(s): Nicola Mason
Category(s): Veterinary & Animal Health, Therapeutics & Vaccines, Diagnostics
A method for highly selective nucleic acid enrichment for sensitive detection of mutations in cancer and genectic conditions.
This technology increases the fraction of clinically relevant, rare mutant alleles (DNA and/or RNA) to enable high sensitivity detection with common downstream methods such as capped (XNA or PNA) PCR, ddPCR, and sequencing. Problem: Liquid biopsy is a simple, minimally invasive, rapidly developing diagnostic method to analyze cell-free nucleic...
Published: 2/7/2020   |   Inventor(s): Jinzhao Song, Haim Bau, Michael Mauk, Jorrit Hegge, John van der Oost
Category(s): Diagnostics, Hardware & Circuits & Sensors, Medical Devices, Research Tools & Reagents, Veterinary & Animal Health
Device to produce traumatic brain injury in model organisms
Research tool for immobilizing animal and precisely inflicting head trauma Problem: Traumatic brain injury (TBI) is a leading cause of neurological deficits, resulting from mechanical forces that deform the brain, along with secondary injuries triggered by molecular responses. TBI outcomes are heterogeneous due to the variation in the location...
Published: 2/6/2020   |   Inventor(s): Nancy Bonini, David Meaney
Category(s): Medical Devices, Research Tools & Reagents, Veterinary & Animal Health
New therapy for skin infections in companion animals
A selective method for treating bacterial skin and ear infections in dogs, cats, and horses. Problem: Pyoderma, or bacterial infection of the skin, is the most common dermatologic problem encountered in cats and dogs. The two main organisms causing pyoderma in companion animals are Staphylococcus pseudintermedius and Staphylococcus schleiferi....
Published: 2/6/2020   |   Inventor(s): Daniel Beiting
Category(s): Veterinary & Animal Health
Protein sequences for therapeutic applications in management of obesity, cachexia and nausea
Non-naturally occurring protein sequences that enhance or suppress the activity of hormone associated with obesity and nausea Problem: Growth differentiation factor-15 (GDF15) is a broadly expressed hormone, whose level often correlates with progression of many diseases. It has been shown in multiple species that the elevated level of GDF15 drives...
Published: 3/27/2019   |   Inventor(s): Ian Tinsley, Tito Borner, Robert Doyle, Bart De Jonghe, Matthew Hayes
Category(s): Therapeutics & Vaccines, Veterinary & Animal Health
Gene therapy for the treatment of retinal degeneration and vision loss
Recombinant adeno-associated virus (rAAV) expressing the gene for retinitis pigmentosa GTPAse regulation (RPGR) for the functional and structural rescue of photoreceptor cells of the eye as gene therapy for retinal degeneration and vision loss. Technology Overview: Retinitis pigmentosa (RP) is a genetic form of early-onset retinal degeneration...
Published: 6/7/2018   |   Inventor(s): William Beltran, Gustavo Aguirre, Artur Cideciyan, Samuel Jacobson
Category(s): Therapeutics & Vaccines, Veterinary & Animal Health
Naturally derived vaccine adjuvant and immunostimulant for use in humans and animals
Unique RNA molecule derived from defective viral genomes containing potent immunostimulatory and adjuvant properties Problem: The vaccine industry is steadily moving away from live-attenuated and whole-pathogen products, mostly due to safety concerns. As this trend continues, there is a need for new adjuvants in the marketplace to help boost the...
Published: 4/28/2016   |   Inventor(s): Carolina Lopez
Category(s): Therapeutics & Vaccines, Research Tools & Reagents, Veterinary & Animal Health