Available Technologies

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Fully human anti-mesothelin CAR with low immunogenicity for in vivo persistence of anti-tumor engineered T cells
The fully human CAR targets mesothelin, a surface protein overexpressed in several cancer types. P4, a human antibody fragment that binds human mesothelin with high specificity, is fused to T cell signaling domains such as 28z. The T cells engineered to express this CAR are shown to shrink tumors in a mouse model bearing human ovarian tumors overexpressing...
Published: 1/29/2020   |   Inventor(s): Daniel Powell
Keywords(s): Antibody, Autoimmune, Cell Therapy, Immunology, Immunoncology, Oncology
Category(s): Therapeutics & Vaccines
Monoclonal antibody to CXCR6
CXCR6 is a chemokine receptor expressed by leukocytes and other cells, and is believed to play a role in cancer metastasis, gut mucosal integrity, autoimmunity, diabetes and other inflammatory disorders. It is also used by SIV as a co-receptor for target cell entry. Technology Overview: Current commercially available monoclonal antibodies that...
Published: 1/28/2020   |   Inventor(s): Ronald Collman
Keywords(s): Antibody, Autoimmune, Oncology
Category(s): Research Tools & Reagents
A method to identify modulators for regulatory T cell functions
Technology Overview: Maintenance of tolerance to self-antigens is essential for the prevention of autoimmunity. This process is known to involve specific regulatory T cells (Treg) and the expression of the forkhead family transcription factor, FOXP3. FOXP3 is a “sufficient” regulator of the development and function of peripheral Treg...
Published: 8/10/2017   |   Inventor(s): Mark Greene
Keywords(s): Autoimmune
Category(s): Research Tools & Reagents