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Search Results - bioengineering

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Lipid nanoparticle-based mRNA delivery for CAR T-cell engineering
A library of ionizable lipid nanoparticles (LNPs) was screened for ability to deliver mRNA to T-cells, leading to an optimized LNP formulation for delivery of mRNA to T-cells. This thereby enhances the ability to generate transient chimeric antigen receptor (CAR)-expressing T-cells for cancer immunotherapy.Problem: Chimeric antigen receptor (CAR) T-cells...
Published: 5/4/2020   |   Inventor(s): Margaret Billingsley, Carl June, Nathan Singh, Michael Mitchell
Keywords(s): Bioengineering, COVID-19, Drug Delivery, Immunology, Immunotherapy
Category(s): Therapeutics & Vaccines
Rapid method to design and screen novel lipid nanoparticles for mRNA delivery in vivo
A platform technology to rapidly identify novel lipid nanoparticle (LNP) formulations to carry mRNA-based therapeutics to target organs/cells in vivo.Problem: Messenger RNA (mRNA) has emerged as a promising new class of nucleic acid therapy, with the potential to induce protein production to treat and prevent a range of diseases. While significant progress...
Published: 5/4/2020   |   Inventor(s): Michael Mitchell, Rui Zhang, Roman Spektor
Keywords(s): Bioengineering, COVID-19
Category(s): Chemical Processes and Synthesis, Research Tools & Reagents, Therapeutics & Vaccines
Stabilized, shear-thinning hydrogels as scaffolds for drug delivery and regenerative medicine
Secondary crosslinking of injectable shear-thinning hydrogels to enhance mechanics and stability Problem: Hydrogels are crosslinked polymers that are used in biomedical applications for culturing cells in vitro or for the delivery of cells or therapeutic molecules in vivo. Injectable hydrogels may be introduced into patients in a minimally invasive...
Published: 3/20/2020   |   Inventor(s): Jason Burdick
Keywords(s): Bioengineering
Category(s): Materials
Classifying high-frequency oscillations in physiological recordings
Method for automatic and unsupervised classification of high-frequency oscillations in physiological recordings. Problem: Automatic detection and classification of high frequency oscillations (HFO) data for use in clinical diagnosis and therapy has been limited. Currently, researchers visually inspect for high frequency oscillations. Solution:...
Published: 3/18/2020   |   Inventor(s): Brian Litt
Keywords(s): Bioengineering, Neurodegenerative Diseases
Category(s): IT & Communication & Networking, Research Tools & Reagents, Imaging, Medical Devices
Genetically engineered bacteria for oral delivery of bioactive proteins, therapeutics, and vaccines
Lactococcus lactis as a vehicle for biotechnological production of proteins and clinical delivery of therapeutics Technology Overview: The Sarkar Lab has genetically engineered the Gram-positive bacteria Lactococcus lactis to secrete a single-chain insulin analog (SCI-57) that is bioactive at gut physiological pH, demonstrating the first functional...
Published: 11/28/2018   |   Inventor(s): Casim Sarkar
Keywords(s): Bioengineering
Category(s): Diagnostics, Therapeutics & Vaccines
Implantable device to treat epilepsy
Diagnostic and preventative implantable device with computer-brain interface for treatment of epilepsy. Problem: One percent of the world’s population suffers from epilepsy. Aside from seizures’ debilitating effects, patients are confined by their unpredictability. Prevention is one way to decrease seizures, but measures usually focus...
Published: 11/27/2018   |   Inventor(s): Brian Litt
Keywords(s): Bioengineering
Category(s): Diagnostics, Therapeutics & Vaccines, Materials, Medical Devices, IT & Communication & Networking