Search Results - daniel+powell

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CD137 enrichment of tumor-specific tumor-infiltrating lymphocytes (TILs)

A platform to isolate and expand CD137-positive (CD137pos) tumor-infiltrating lymphocytes (TILs) to use in adoptive immunotherapy and translational studies.

Published: 4/2/2024
Inventor(s):
Daniel Powell
Keywords(s):
CAR T-cell Enhancing Technology, Cell Therapy, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s):
Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Vaccines

CAR T cell therapy for the treatment of ovarian cancer and other gynecologic malignancies

Anti-Mullerian inhibiting substance type II receptor (MISRII) specific CAR T cell therapy for the targeted, safe treatment of ovarian cancer.

Published: 10/16/2023
Inventor(s):
Daniel Powell, Alba Rodriguez-Garcia
Keywords(s):
 
Category(s):
Technology Classifications > Therapeutics

Fully human anti-mesothelin CAR with low immunogenicity for in vivo persistence of anti-tumor engineered T cells

The fully human CAR targets mesothelin, a surface protein overexpressed in several cancer types. P4, a human antibody fragment that binds human mesothelin with high specificity, is fused to T cell signaling domains such as 28z. The T cells engineered to express this CAR are shown to shrink tumors in a mouse model bearing human ovarian tumors overexpressing mesothelin. 

Published: 4/2/2024
Inventor(s):
Daniel Powell
Keywords(s):
Antibody, Cell Therapy, Immunology, Immunoncology, Oncology
Category(s):
Technology Classifications > Therapeutics

Single viral vector for expression of both CAR/TCR and immune modulators for cancer immunotherapy

A single lentiviral vector system as an expression platform for constitutive immune receptor expression and inducible antigen-dependent immunomodulatory molecule expression in primary immune cells for enhanced immunotherapy efficacy

Published: 1/23/2024
Inventor(s):
Daniel Powell, Anze Smole, Avery Posey
Keywords(s):
CAR T-cell Enhancing Technology
Category(s):
Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics