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New designs of arginase inhibitors as therapeutic and diagnostic agents

Technology Overview: Researchers in the Christianson Lab have designed arginase inhibitors that bind to arginase I and II, and conducted structural analyses of several three-dimensional crystal structures with arginase-inhibitor complexes. Inhibiting arginase enhances nitric oxide-dependent smooth muscle relaxation, including gastrointestinal, airway,...

Published: 3/10/2020

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