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Rapid pathogen diagnostic through amplification of red blood cell-associated DNA
Problem: Sepsis, an overwhelming and life-threatening response to infection, is the most common cause of death in US hospitals. Sepsis is associated with a mortality rate of 25–30% and mortality due to septic shock is 50–85%. Rapid diagnosis and intervention in sepsis are essential given an increased mortality rate of 8% for every hour...
Published:
11/24/2020
Inventor(s):
Nilam Mangalmurti
Keywords(s):
COVID-19
,
Immunology
,
Infectious Disease
,
Inflammation
Category(s):
Diagnostics
Rapid and ultrasensitive SARS-CoV-2 antigen detection for acute COVID-19 screening in community settings
A portable point-of-care device for rapid and sensitive detection of acute SARS-CoV-2 infections. Problem: The COVID-19 pandemic has infected over 40 million people worldwide as of mid-October 2020, causing more than 1 million deaths. Up to 50-80% of transmissions occur from asymptomatic patients. Current tests can have a turnaround time of hours...
Published:
11/11/2020
Inventor(s):
Ping Wang
Keywords(s):
COVID-19
,
Immunology
,
Infectious Disease
,
Microfluidics
,
Pulmonary
Category(s):
Diagnostics
Low-cost rapid diagnostic for COVID-19
A COVID-19 diagnostic approach, utilizing a SARS-CoV-2 binding biosensor, that allows for real-time virus detection, without the need for sample processing, ultimately leading to population-level surveillance, outbreak tracking, reduced healthcare costs, improved treatment outcomes, and saved lives. Problem: SARS-CoV-2, the virus that causes COVID-19,...
Published:
11/5/2020
Inventor(s):
Cesar de la Fuente
,
Marcelo Der Torossian Torres
,
William Reis de Araujo
Keywords(s):
Bioengineering
,
COVID-19
,
Infectious Disease
Category(s):
Diagnostics
,
Digital Health
,
Hardware & Circuits & Sensors
Antibodies for targeting CAR-T cells to acute Myeloid Leukemia cells
Technology Overview: Acute myeloid leukemia (AML) is a major form of acute leukemia in elder adults. The treatment of AML has changed little in the past decades and the overall 5-year survival rate remains very poor in the AML patients. AML relapsed from chemotherapy is highly aggressive with poor prognosis. While adaptive cell therapy via chimeric...
Published:
11/5/2020
Inventor(s):
Xianxin Hua
Keywords(s):
Category(s):
Diagnostics
,
Imaging
,
Therapeutics & Vaccines
Rapid and ultrasensitive profiling of EGFRvIII mutations in cancer and normal tissue
A method to rapidly detect the presence of EGFRvIII mutations in cancers and normal tissue using digital PCR. Problem: Glioblastoma multiforme (GBM) is a devastating brain cancer with poor prognosis. EGFRvIII is a mutation in the Extracellular Growth Factor Receptor that frequently occurs in GBM tumors. Targeting EGFRvIII mutations is an emerging...
Published:
10/5/2020
Inventor(s):
Deeksha Saxena
,
Jay Dorsey
,
Gary Kao
,
Donald O'Rourke
,
Maclean Nasrallah
Keywords(s):
Cell Therapy
,
Immunoncology
,
Oncology
Category(s):
Chemical Processes and Synthesis
,
Diagnostics
,
Research Tools & Reagents
A Smart Cryostat or “Smart Cut”
A cryostat with optical imaging capabilities to detect cancerous tissue using near-infrared (NIR) imaging and artificial intelligence software. Problem: During surgery, biopsies are taken for pathologists to examine and answer the following questions: (a) did the surgery locate the tumor? (b) is the margin of the tumor removal site tumor free...
Published:
5/6/2020
Inventor(s):
Sunil Singhal
,
Lydia Frenzel Sulyok
,
Mitchell Bryski
Keywords(s):
Category(s):
Diagnostics
,
Software & Data & Algorithms & Apps
Novel blood biomarker predicting brain damage and long-term dysfunction after concussion
Rapid diagnostic and prognostic marker predicting risk of brain damage and lasting dysfunction after mild traumatic brain injury (mTBI or concussion) Problem: Mild traumatic brain injury (mTBI), alternatively referred to as concussion, is the most common neurological injury. mTBI affects more than 1.5 million children and adults each year in the...
Published:
3/20/2020
Inventor(s):
Robert Siman
Keywords(s):
Category(s):
Diagnostics
Heart disease diagnostic and prognostic
Indicators for treatment of bicuspid aortic valve and aortopathies. Problem: Bicupsid aortic valve (BAV) is the most common congenital heart defect in the US, with an approximate incidence of 1 in 50 births. BAV frequently leads to valve dysfunction and is associated with serious adverse aortic events such as aortic aneurysm, dissection and rupture....
Published:
3/20/2020
Inventor(s):
Giovanni Ferrari
,
Emanuela Branchetti
Keywords(s):
Category(s):
Diagnostics
Hyperpolarized gas delivery to subject in MRI scanner for enhanced pulmonary
diagnostics
and disease progression monitoring
Device for the optimal mixing and delivery of MRI gaseous contrast agents Problem: Gaseous contrast agents, and more specifically, hyperpolarized (HP) noble gases, such as helium-3 and xenon-129, are used for investigational imaging of respiratory gas in lungs by MRI for the purpose of assessing regional lung function. The ultimate goals of such...
Published:
3/20/2020
Inventor(s):
Kiarash Emami
,
Stephen Kadlecek
Keywords(s):
Category(s):
Diagnostics
,
Imaging
,
Medical Devices
Antibodies for targeting CAR-T cells to neuroendocrine tumors
Technology Overview: Neuroendocrine tumors (NETs) pose serious threats to patients’ well-being as malignant diseases, and most patients with metastatic NETs succumb to the disease. Using Sequential Tumor-related Antibody and antigen Retrieving (STAR) technology Dr. Xianxin Hua, MD, PhD at the University of Pennsylvania Medical School and his...
Published:
3/20/2020
Inventor(s):
Xianxin Hua
Keywords(s):
Category(s):
Diagnostics
,
Imaging
,
Therapeutics & Vaccines
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