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Novel blood biomarker predicting brain damage and long-term dysfunction after concussion

Rapid diagnostic and prognostic marker predicting risk of brain damage and lasting dysfunction after mild traumatic brain injury (mTBI or concussion) Problem: Mild traumatic brain injury (mTBI), alternatively referred to as concussion, is the most common neurological injury. mTBI affects more than 1.5 million children and adults each year in the...

Published: 6/23/2021

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A homogenous self-heating, temperature-regulating composite material

A cost-effective homogenous, composite material provides sustained heat at a desired temperature for point-of-care diagnostics and other applications. Problem: Point-of-care (POC) diagnostic tests have the potential to greatly enhance patient care and accessibility by reducing the time and equipment necessary for testing. Many current POC tests require...

Published: 5/7/2021

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Method to determine risk of preterm birth

Problem: Preterm birth accounts for ~12% of all births in the US and costs an estimated $26.2 billion each year. Current methods for identifying patients at risk for preterm birth rely on socioeconomic, behavioral, and clinical factors such as age, tobacco use, or previous preterm birth, respectively. Although there are numerous factors known to be...

Published: 4/27/2021

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Rapid pathogen diagnostic through amplification of red blood cell-associated DNA

Problem: Sepsis, an overwhelming and life-threatening response to infection, is the most common cause of death in US hospitals. Sepsis is associated with a mortality rate of 25–30% and mortality due to septic shock is 50–85%. Rapid diagnosis and intervention in sepsis are essential given an increased mortality rate of 8% for every hour...

Published: 11/24/2020

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Rapid and ultrasensitive SARS-CoV-2 antigen detection for acute COVID-19 screening in community settings

rss.brief>A portable point-of-care device for rapid and sensitive detection of acute SARS-CoV-2 infections. Problem: The COVID-19 pandemic has infected over 40 million people worldwide as of mid-October 2020, causing more than 1 million deaths. Up to 50-80% of transmissions occur from asymptomatic patients. Current tests can have a turnaround time...

Published: 11/11/2020

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Low-cost rapid diagnostic for COVID-19

A COVID-19 diagnostic approach, utilizing a SARS-CoV-2 binding biosensor, that allows for real-time virus detection, without the need for sample processing, ultimately leading to population-level surveillance, outbreak tracking, reduced healthcare costs, improved treatment outcomes, and saved lives. Problem: SARS-CoV-2, the virus that causes COVID-19,...

Published: 11/5/2020

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Antibodies for targeting CAR-T cells to acute Myeloid Leukemia cells

Technology Overview: Acute myeloid leukemia (AML) is a major form of acute leukemia in elder adults. The treatment of AML has changed little in the past decades and the overall 5-year survival rate remains very poor in the AML patients. AML relapsed from chemotherapy is highly aggressive with poor prognosis. While adaptive cell therapy via chimeric...

Published: 11/5/2020

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Antibody discovery platform for CAR-T cell targeting and drug conjugation

Technology Overview: Screening platform for identification of potent and specific nanobodies for (i) directing CAR-T cells to cancer cells, (ii) drug conjugation, or (iii) tumor imaging or diagnosis. Identification of antibodies capable of mediating CAR-T killing is challenging due to several reasons. First, the antibody has to have certain affinity...

Published: 11/2/2020

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Rapid and ultrasensitive profiling of EGFRvIII mutations in cancer and normal tissue

A method to rapidly detect the presence of EGFRvIII mutations in cancers and normal tissue using digital PCR. Problem: Glioblastoma multiforme (GBM) is a devastating brain cancer with poor prognosis. EGFRvIII is a mutation in the Extracellular Growth Factor Receptor that frequently occurs in GBM tumors. Targeting EGFRvIII mutations is an emerging...

Published: 10/5/2020

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A smart cryostat or “Smart Cut”

A cryostat with optical imaging capabilities to detect cancerous tissue using near-infrared (NIR) imaging and artificial intelligence software. Problem: During surgery, biopsies are taken for pathologists to examine and answer the following questions: (a) did the surgery locate the tumor? (b) is the margin of the tumor removal site tumor free ? and...

Published: 5/6/2020

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