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Rapid pathogen diagnostic through amplification of red blood cell-associated DNA

Problem: Sepsis, an overwhelming and life-threatening response to infection, is the most common cause of death in US hospitals. Sepsis is associated with a mortality rate of 25–30% and mortality due to septic shock is 50–85%. Rapid diagnosis and intervention in sepsis are essential given an increased mortality rate of 8% for every hour...

Published: 11/24/2020

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Rapid and ultrasensitive SARS-CoV-2 antigen detection for acute COVID-19 screening in community settings

A portable point-of-care device for rapid and sensitive detection of acute SARS-CoV-2 infections. Problem: The COVID-19 pandemic has infected over 40 million people worldwide as of mid-October 2020, causing more than 1 million deaths. Up to 50-80% of transmissions occur from asymptomatic patients. Current tests can have a turnaround time of hours...

Published: 11/11/2020

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Low-cost rapid diagnostic for COVID-19

A COVID-19 diagnostic approach, utilizing a SARS-CoV-2 binding biosensor, that allows for real-time virus detection, without the need for sample processing, ultimately leading to population-level surveillance, outbreak tracking, reduced healthcare costs, improved treatment outcomes, and saved lives. Problem: SARS-CoV-2, the virus that causes COVID-19,...

Published: 11/5/2020

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Antibodies for targeting CAR-T cells to acute Myeloid Leukemia cells

Technology Overview: Acute myeloid leukemia (AML) is a major form of acute leukemia in elder adults. The treatment of AML has changed little in the past decades and the overall 5-year survival rate remains very poor in the AML patients. AML relapsed from chemotherapy is highly aggressive with poor prognosis. While adaptive cell therapy via chimeric...

Published: 11/5/2020

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Rapid and ultrasensitive profiling of EGFRvIII mutations in cancer and normal tissue

A method to rapidly detect the presence of EGFRvIII mutations in cancers and normal tissue using digital PCR. Problem: Glioblastoma multiforme (GBM) is a devastating brain cancer with poor prognosis. EGFRvIII is a mutation in the Extracellular Growth Factor Receptor that frequently occurs in GBM tumors. Targeting EGFRvIII mutations is an emerging...

Published: 10/5/2020

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A Smart Cryostat or “Smart Cut”

A cryostat with optical imaging capabilities to detect cancerous tissue using near-infrared (NIR) imaging and artificial intelligence software. Problem: During surgery, biopsies are taken for pathologists to examine and answer the following questions: (a) did the surgery locate the tumor? (b) is the margin of the tumor removal site tumor free...

Published: 5/6/2020

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Novel blood biomarker predicting brain damage and long-term dysfunction after concussion

Rapid diagnostic and prognostic marker predicting risk of brain damage and lasting dysfunction after mild traumatic brain injury (mTBI or concussion) Problem: Mild traumatic brain injury (mTBI), alternatively referred to as concussion, is the most common neurological injury. mTBI affects more than 1.5 million children and adults each year in the...

Published: 3/20/2020

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Heart disease diagnostic and prognostic

Indicators for treatment of bicuspid aortic valve and aortopathies. Problem: Bicupsid aortic valve (BAV) is the most common congenital heart defect in the US, with an approximate incidence of 1 in 50 births. BAV frequently leads to valve dysfunction and is associated with serious adverse aortic events such as aortic aneurysm, dissection and rupture....

Published: 3/20/2020

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Hyperpolarized gas delivery to subject in MRI scanner for enhanced pulmonary diagnostics and disease progression monitoring

Device for the optimal mixing and delivery of MRI gaseous contrast agents Problem: Gaseous contrast agents, and more specifically, hyperpolarized (HP) noble gases, such as helium-3 and xenon-129, are used for investigational imaging of respiratory gas in lungs by MRI for the purpose of assessing regional lung function. The ultimate goals of such...

Published: 3/20/2020

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Antibodies for targeting CAR-T cells to neuroendocrine tumors

Technology Overview: Neuroendocrine tumors (NETs) pose serious threats to patients’ well-being as malignant diseases, and most patients with metastatic NETs succumb to the disease. Using Sequential Tumor-related Antibody and antigen Retrieving (STAR) technology Dr. Xianxin Hua, MD, PhD at the University of Pennsylvania Medical School and his...

Published: 3/20/2020

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