Innovation at Penn
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Search Results - donald+o%27rourke
Rapid and ultrasensitive profiling of EGFRvIII mutations in cancer and normal tissue
A method to rapidly detect the presence of EGFRvIII mutations in cancers and normal tissue using digital PCR. Problem: Glioblastoma multiforme (GBM) is a devastating brain cancer with poor prognosis. EGFRvIII is a mutation in the Extracellular Growth Factor Receptor that frequently occurs in GBM tumors. Targeting EGFRvIII mutations is an emerging...
Chemical Processes and Synthesis
Research Tools & Reagents
Non-invasive detection of EGFRvIII mutations in Glioblastoma using MRI
Technology Overview: GBM has a highly variable molecular, spatial and temporal fingerprint making analysis difficult. Current methods require tissue biopsies which fail to capture the heterogeneity of GBM, and damage healthy tissue. Epidermal growth factor receptor (EGFR), a cell growth regulator, is mutated and/or overexpressed in most intractable...
Software & Data & Algorithms & Apps
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